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GDC-0980 is an inhibitor of PI3K and mTORC1/2 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. GDC-0980 inhibits cell growth in uterine serous carcinoma cells and decreases vascular density by altering vascular permeability parameter K (trans) in other cellular models. GDC-0980 inhibits cell growth and tumor growth across many cancer cell lines and models, including breast cancer, prostate cancer, and lung cancer.
| Cas No. | 1032754-93-0 |
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| Purity | ≥98% |
| Formula | C23H30N8O3S |
| Formula Wt. | 498.60 |
| IUPAC Name | (2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one |
| Synonym | RG7422, Apitolisib, GNE 390 |
| Solubility | DMSO 20 mg/mL (40.11 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet | |
| Brochures |
English DP, Bellone S, Cocco E, et al. Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). Am J Obstet Gynecol. 2013 Nov;209(5):465.e1-9. PMID: 23891627.
Sampath D, Oeh J, Wyatt SK, et al. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul;15(7):694-711. PMID: 23814482.
Wallin JJ, Edgar KA, Guan J, et al. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther. 2011 Dec;10(12):2426-36. PMID: 21998291.