Ginsenoside F2

Name: Ginsenoside F2
SKU: G3461
Availability: InStock

Product ID G3461

Cas No. 62025-49-4

Purity ≥98%

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Description

Ginsenoside F2 is a triterpene saponin originally found in species of Panax that exhibits anti-obesity and anticancer chemotherapeutic activities. Ginsenoside F2 inhibits hair cell apoptosis, decreasing expression of TGF-β2, SCAP, and SREBP in vivo. Ginsenoside F2 also decreases lipid accumulation in adipocytes, suppressing expressing of PPARγ and perilipin and inhibiting adipogenesis. This compound also induces formation of acidic vesicles, autophagy, and mitochondrial apoptosis in breast cancer stem cells; additionally, it decreases tumor growth in animal models of glioblastoma.

Product Info

Cas No.	62025-49-4
Purity	≥98%
Formula	C₄₂H₇₂O₁₃
Formula Wt.	785.03
IUPAC Name	(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-3,4,5-triol
Appearance	White to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	G3461 MSDS PDF
Info Sheet	G3461 Info Sheet PDF

References

Shin HS, Park SY, Hwang ES, et al. Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model. Biol Pharm Bull. 2014;37(5):755-63. PMID: 24789999.

Siraj FM, Sathishkumar N, Kim YJ, et al. Ginsenoside F2 possesses anti-obesity activity via binding with PPARγ and inhibiting adipocyte differentiation in the 3T3-L1 cell line. J Enzyme Inhib Med Chem. 2014 Mar 25. [Epub ahead of print]. PMID: 24666293.

Mai TT, Moon J, Song Y, et al. Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells. Cancer Lett. 2012 Aug 28;321(2):144-53. PMID: 22326284.

Quan LH, Piao JY, Min JW, et al. Biotransformation of Ginsenoside Rb1 to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F2, and Compound K by Leuconostoc mesenteroides DC102. J Ginseng Res. 2011 Sep;35(3):344-51. PMID: 23717079.

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Ginsenoside F2

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Description

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