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GSK-2126458

GSK-2126458

Product ID G7342
Cas No. 1086062-66-9
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $67.80 In stock
5 mg $127.90 In stock
25 mg $390.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GSK-2126458 is an ATP-competitive PI3K and mTOR inhibitor somewhat specific for the p110α isoform of PI3K. This compound exhibits anticancer chemotherapeutic activity, inhibiting growth in cellular models. GSK-2126458 is currently in clinical trials for treatment of a variety of solid tumor cancers.

Product Info

Cas No.

1086062-66-9

Purity

≥99%

Formula

C25H17F2N5O3S

Formula Wt.

505.50

Chemical Name

2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl] benzenesulfonamide

IUPAC Name

2, 4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl] benzenesulfonamide

Synonym

GSK458, Omipalisib

Solubility

DMSO 100 mg/mL (197.82 mM) Water Insoluble Ethanol Insoluble

Appearance

light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G7342 MSDS PDF

Info Sheet

G7342 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Greger JG, Eastman SD, Zhang V, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther. 2012 Apr;11(4):909-20. PMID: 22389471.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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