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GSK-2830371 is an inhibitor of wild-type p53-induced phosphatase 1 (Wip1) that exhibits anticancer chemotherapeutic activity. In animal models of lymphoma, GSK-2830371 inhibits cell growth and tumor growth. In neuroblastoma cells, this compound induces cell death.
| Cas No. | 1404456-53-6 |
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| Purity | ≥98% |
| Formula | C23H29ClN4O2S |
| Formula Wt. | 461.02 |
| IUPAC Name | 5-{[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl}-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxo-2-propanyl]-2-thiophenecarboxamide |
| Solubility | DMSO 92 mg/mL (199.55 mM) Ethanol 92 mg/mL warmed (199.55 mM) Water Insoluble |
| Appearance | Yellow to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Richter M, Dayaram T, Gilmartin AG, et al. WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma. PLoS One. 2015 Feb 6;10(2):e0115635. PMID: 25658463.
Gilmartin AG, Faitg TH, Richter M, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10(3):181-7. PMID: 24390428.