• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Herbimycin A

Herbimycin A

Product ID H1669
Cas No. 70563-58-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $539.70 Please Inquire
1 mg $1,277.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Herbimycin A is a benzoquinone ansamycin antibiotic that also exhibits anticancer activity. Herbimycin A inhibits HSP90, PKC, and some Src family kinases such as Src and Bcr-Abl. Herbimycin A inhibits cell proliferation in various in vitro cancer models, including chronic myelogenous leukemia (CML).

Product Info

Cas No.

70563-58-5

Purity

≥98%

Formula

C30H42N2O9

Formula Wt.

574.66

IUPAC Name

[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9, 15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate

Synonym

Herbimycin

Solubility

Soluble in DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H1669 MSDS PDF

Info Sheet

H1669 Info Sheet PDF

References

Kasai S, Kikuchi H. The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci Biotechnol Biochem. 2010;74(1):36-43. PMID: 20057149.

Napolitano M, Bravo E. Activation of protein kinase C by phorbol esters in human macrophages reduces the metabolism of modified LDL by down-regulation of scavenger receptor activity. Int J Biochem Cell Biol. 2003 Jul;35(7):1127-43. PMID: 12672483.

Mucha DR, Myers CL, Schaeffer RC Jr. Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase. Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H994-H1002. PMID: 12456392.

Ren H, Chen S, Lu D. Herbimycin A enhances apoptotic effect of chemotherapeutic drugs on K562 cells. Chin Med J (Engl). 1998 Aug;111(8):678-81. PMID: 11245017.

Fukazawa H, Li PM, Yamamoto C, et al. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochem Pharmacol. 1991 Oct 9;42(9):1661-71. PMID: 1656993.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • I5210

    INCB018424

    JAK1/2 inhibitor.

    ≥98%
  • E7668

    Etretinate

    Aromatic retinoid; RAR, RXR agonist.

    ≥98%
  • L8011

    D-Luciferin Sodium

    Heterocyclic light-emitting compound, natural l...

    ≥99%
  • D5607

    Dobutamine Hydrochloride

    β1-adrenergic agonist, β2- and α1-adrenergic...

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • S680000

    SR144528

    Selective cannabinoid receptor 2 (CB2) inverse ...

    ≥98%
  • M188776

    9-(Methylsulfonyl)nonanyl nitrile

    Synthetic nitrile compound

    ≥98%
  • P6852

    Propafenone Hydrochloride

    β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...

    ≥98%
  • H1893

    Hexarelin

    Synthetic ghrelin analog; ghrelin agonist.

    ≥95%
  • M1626

    Megestrol Acetate

    Synthetic progestogen, orexigenic.

    ≥98%
  • F4582

    Fluocinolone Acetonide

    Synthetic hydrocortisone derivative; glucocorti...

    ≥98%
  • I7256

    Isobavachalcone

    Prenylated chalcone flavonoid found in Psoralea...

    ≥97%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • L8248

    Lumiracoxib

    NSAID; COX-2 inhibitor.

    ≥98%
  • P7158

    Protopine

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only