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Hexestrol is a synthetic catechol that exhibits carcinogenic and estrogenic activities. Hexestrol inhibits tubulin assembly and induces mitotic arrest and aneuploidy in vitro. Hexestrol also forms DNA adducts, potentially initiating carcinogenesis.
| Cas No. | 84-16-2 |
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| Purity | ≥98% |
| Formula | C18H22O2 |
| Formula Wt. | 270.37 |
| Chemical Name | 4,4'-(1,2-Diethylethyl-1,2-ethanediyl)bisphenol |
| IUPAC Name | 4-[4-(4-hydroxyphenyl)hexan-3-yl]phenol |
| Synonym | Dihydrodiethylstilbestrol, Synthovo, Cycloestrol, Hormoestrol, Syntrogene |
| Melting Point | 185-188°C |
| Solubility | Soluble in ether, acetone, alcohol, and methanol. Slightly soluble in benzene and chloroform. |
| Appearance | White or Almost White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cavalieri EL, Rogan EG. A unifying mechanism in the initiation of cancer and other diseases by catechol quinones. Ann N Y Acad Sci. 2004 Dec;1028:247-57. PMID: 15650250.
Chaudoreille MM, Peyrot V, Braguer D, et al. Qualitative study of the interaction mechanism of estrogenic drugs with tubulin. Biochem Pharmacol. 1991 Mar 1;41(5):685-93. PMID: 1847811.
Wheeler WJ, Cherry LM, Downs T, et al. Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro. Mutat Res. 1986 Jul;171(1):31-41. PMID: 3724781.