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HU 308

HU 308

Product ID H800010
Cas No. 256934-39-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $68.60 In stock
5 mg $279.10 In stock
25 mg $1,073.30 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

HU 308 is a selective cannabinoid receptor 2 (CB2) agonist. Activation of the CB2 receptor produces a variety of results in cancer, neuroscience and immunology. Recent studies with HU 308 show activity in immunomodulatory systems. HU 308, in neuroprogentor cells, induces cellular motility by activation of the PI3-K/Akt/mTORC pathway. HU-308 activates macrophage chemotaxis, albeit without activity the CB2 receptor.

Product Info

Cas No.

256934-39-1

Purity

≥98%

Formula

C27H42O3

Formula Wt.

414.63

Chemical Name

[(1R,2S,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol

IUPAC Name

[(1R,2S,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol

Synonym

HU-308

Solubility

100mM in DMSO, 100mM in ethanol

Appearance

Clear film

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H800010 MSDS PDF

Info Sheet

H800010 Info Sheet PDF

References

Hanus L, Breuer A, Tchilibon S et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci USA. 1999 Dec 7;96(25):14228-33. PMID: 10588688.

Palazuelos J, Ortega Z, Diaz-Alonso J et al. CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. J Biol Chem. 2012 Jan 6;287(2):1198-209. PMID: 22102284.

Taylor L, Christou I, Kapellos TS, et al. Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Indepenently of the CB2 Receptor. Sci Rep. 2015 Jun 2;5:10682. PMID: 26033291.

Custom Order

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