• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Hydrochlorothiazide

Hydrochlorothiazide

Product ID H9614
Cas No. 58-93-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $54.60 In stock
5 g $88.10 In stock
25 g $163.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Hydrochlorothiazide (HCT) is an antihypertensive thiazide diuretic that is used to treat hypertension and chronic kidney disease. HCT competes for the Cl- site on the Na+/Cl- co-transporter (NCCT), decreasing reabsorption of Na+ in the distal convoluted tubule, inducing natriuresis and decreasing blood volume. HCT also partially inhibits carbonic anhydrase I in erythrocytes and vascular smooth muscle cells; this mechanism may be behind the ability of HCT to decrease peripheral vascular resistance and blood pressure. Separately, HCT may also increase reabsorption of Ca2+. This compound may also exhibit anticancer chemotherapeutic benefit in conjunction with UVA light, as it enhances production of TT dimers in vitro and in vivo.

Product Info

Cas No.

58-93-5

Purity

≥98%

Formula

C7H8ClN3O4S2

Formula Wt.

297.74

Chemical Name

6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

IUPAC Name

6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2, 4-benzothiadiazine-7-sulfonamide

Melting Point

274°C

Solubility

200 mM ethanol; 100 mM 50% ethanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

H9614 MSDS PDF

Info Sheet

H9614 Info Sheet PDF

References

Kunisada M, Masaki T, Ono R, et al. Hydrochlorothiazide enhances UVA-induced DNA damage. Photochem Photobiol. 2013 May-Jun;89(3):649-54. PMID: 23331297.

Karadsheh F, Weir MR. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Curr Hypertens Rep. 2012 Oct;14(5):416-20. PMID: 22886538.

Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. PMID: 20528637.

Puscas I, Coltau M, Baican M, et al. Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. PMID: 10713865.

Shirley DG, Walter SJ, Laycock JF. The role of sodium depletion in hydrochlorothiazide-induced antidiuresis in Brattleboro rats with diabetes insipidus. Clin Sci Mol Med. 1978 Mar;54(3):209-15. PMID: 630797.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E4417

    Eledoisin Related Peptide

    Peptide, substance P analog; NK agonist.

    ≥95%
  • M0172

    Mastoparan

    Antimicrobial peptide found in Vespula lewisii,...

    ≥95%
  • B177550

    Benzbromarone

    Non-competitive inhibitor of xanthine oxidase.<...

    ≥99%
  • L0209

    Lactoferrin, cow

    Endogenous glycoprotein; lactoferrin agonist.

    ≥92%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • B1879

    Betamethasone Valerate

    Synthetic steroid hormone; glucocorticoid agoni...

    ≥98%
  • T2970

    Thrombin Receptor Agonist Peptide

    Peptide; PAR1 agonist.

    ≥95%
  • S520011

    SN-011

    STING antagonist

    ≥97%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • F334451

    Filipin Complex

    A probe for cholesterol in biological membranes...

    ≥97%
  • T7037

    Triptorelin Acetate

    Peptide, GnRH analog.

    ≥95%
  • P6977

    Pyr-GR-pNA

    Fluorogenic substrate used to measure serine pr...

    ≥98%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • A5032

    D,L-Aminoglutethimide

    Aromatase inhibitor.

    ≥98%
  • R1780

    trans-Retinoic Acid

    Vitamin A carboxylic acid; RAR agonist.

    ≥98%
  • C0375

    Ac-DEVD-pNA

    Caspase 3 substrate.

    ≥95%
  • D3355

    Diosgenin

    Steroidal saponin found in Dioscorea.

    ≥98%
  • I538583

    Inosine

    Adenosine analog

    ≥98%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • A5277

    Angiotensin II, human

    Endogenous peptide, involved in vasoconstrictio...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only