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Isatin

Isatin

Product ID I7302
Cas No. 91-56-5
Purity ≥97%
Product Unit SizeCostQuantityStock
100 g $61.10 In stock
500 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isatin is an indole derivative found in Isatis, Calanthe, and Couroupita that exhibits anti-inflammatory, antioxidative, neuromodulatory, and anticancer chemotherapeutic activities. Isatin prevents TNBS-induced increases in TNF-α, COX-2, and PGE2 levels as well as decreases in SOD and GSH levels, protecting against colitis-induced injuries in animal models. Isatin also inhibits monoamine oxidase B (MAO-B) and guanylate cyclase (natriuretic peptide receptors). Schiff base derivatives of isatin inhibit the growth of various cancer cells and tumors, likely due to decreasing cyclin B1 and Cdc2 expression and inducing G2/M phase cell cycle arrest. Derivatives of isatin also inhibit tubulin polymerization, Akt activation, and caspases 3, 7, and 9. Isatin may also exhibit antiepileptic/anticonvulsant activity.

Product Info

Cas No.

91-56-5

Purity

≥97%

Formula

C8H5NO2

Formula Wt.

147.13

Chemical Name

Indole-2,3-dione

IUPAC Name

1H-indole-2,3-dione

Synonym

2,3-Indolinedione, 2,3-Diketoindoline

Melting Point

203.5°C (partial subliminati°n)

Solubility

Soluble in boiling alcohol, ether, boiling water and alkali hydroxide.

Appearance

Red Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I7302 MSDS PDF

Info Sheet

I7302 Info Sheet PDF

References

Liang C, Xia J, Lei D, et al. Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin. Eur J Med Chem. 2014 Mar 3;74:742-50. PMID: 24176732.

Socca EA, Luiz-Ferreira A, de Faria FM, et al. Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Chem Biol Interact. 2014 Feb 25;209:48-55. PMID: 24316276.

Krishnegowda G, Prakasha Gowda AS, Tagaram HR, et al. Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Bioorg Med Chem. 2011 Oct 15;19(20):6006-14. PMID: 21920762.

Chu W, Rothfuss J, d'Avignon A, et al. Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem. 2007 Jul 26;50(15):3751-5. PMID: 17585855.

Malawska B. New anticonvulsant agents. Curr Top Med Chem. 2005;5(1):69-85. PMID: 15638779.

Edmondson DE, Mattevi A, Binda C, et al. Structure and mechanism of monoamine oxidase. Curr Med Chem. 2004 Aug;11(15):1983-93. PMID: 15279562.

Medvedev AE, Sandler M, Glover V. Interaction of isatin with type-A natriuretic peptide receptor: possible mechanism. Life Sci. 1998;62(26):2391-8. PMID: 9651105.

Custom Order

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