• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Isatin

Isatin

Product ID I7302
Cas No. 91-56-5
Purity ≥97%
Product Unit SizeCostQuantityStock
100 g $61.10 In stock
500 g $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Isatin is an indole derivative found in Isatis, Calanthe, and Couroupita that exhibits anti-inflammatory, antioxidative, neuromodulatory, and anticancer chemotherapeutic activities. Isatin prevents TNBS-induced increases in TNF-α, COX-2, and PGE2 levels as well as decreases in SOD and GSH levels, protecting against colitis-induced injuries in animal models. Isatin also inhibits monoamine oxidase B (MAO-B) and guanylate cyclase (natriuretic peptide receptors). Schiff base derivatives of isatin inhibit the growth of various cancer cells and tumors, likely due to decreasing cyclin B1 and Cdc2 expression and inducing G2/M phase cell cycle arrest. Derivatives of isatin also inhibit tubulin polymerization, Akt activation, and caspases 3, 7, and 9. Isatin may also exhibit antiepileptic/anticonvulsant activity.

Product Info

Cas No.

91-56-5

Purity

≥97%

Formula

C8H5NO2

Formula Wt.

147.13

Chemical Name

Indole-2,3-dione

IUPAC Name

1H-indole-2,3-dione

Synonym

2,3-Indolinedione, 2,3-Diketoindoline

Melting Point

203.5°C (partial subliminati°n)

Solubility

Soluble in boiling alcohol, ether, boiling water and alkali hydroxide.

Appearance

Red Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I7302 MSDS PDF

Info Sheet

I7302 Info Sheet PDF

References

Liang C, Xia J, Lei D, et al. Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin. Eur J Med Chem. 2014 Mar 3;74:742-50. PMID: 24176732.

Socca EA, Luiz-Ferreira A, de Faria FM, et al. Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Chem Biol Interact. 2014 Feb 25;209:48-55. PMID: 24316276.

Krishnegowda G, Prakasha Gowda AS, Tagaram HR, et al. Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Bioorg Med Chem. 2011 Oct 15;19(20):6006-14. PMID: 21920762.

Chu W, Rothfuss J, d'Avignon A, et al. Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem. 2007 Jul 26;50(15):3751-5. PMID: 17585855.

Malawska B. New anticonvulsant agents. Curr Top Med Chem. 2005;5(1):69-85. PMID: 15638779.

Edmondson DE, Mattevi A, Binda C, et al. Structure and mechanism of monoamine oxidase. Curr Med Chem. 2004 Aug;11(15):1983-93. PMID: 15279562.

Medvedev AE, Sandler M, Glover V. Interaction of isatin with type-A natriuretic peptide receptor: possible mechanism. Life Sci. 1998;62(26):2391-8. PMID: 9651105.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O486188

    Omeprazole Impurity F and G mixture

    Regioisomers

    ≥98%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • A480020

    (R,S)-AM 1241

    Cannabinoid receptor 2 selective agonist.

    ≥96%
  • V0144

    n-Valeric Acid

    GHB/GABA analog found in Valeriana officinalis;...

    ≥99%
  • E4785

    Elvitegravir

    Integrase inhibitor.

    ≥98%
  • N1894

    Nexturastat A

    HDAC6 inhibitor.

    ≥98%
  • U6801

    Urapidil

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • L960004

    LY-404187

    Selective positive allosteric modulator of AMPA...

    ≥98%
  • C3449

    Clodronate Disodium Tetrahydrate

    Non-nitrogen bisphosphonate; mitochondrial ATP/...

    ≥98%
  • U682042

    URB602

    Inhibitor of Monoacyglycerol lipase (MAGL).

    ≥98%
  • C4502

    Clarithromycin

    Macrolide; protein translation inhibitor.

    ≥95%
  • K0034

    Kahweol Eicosanate

    Diterpene found in coffee beans.

    ≥98%
  • S6000

    Sparfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A7202

    AS-604850

    p110γ PI3K inhibitor.

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • P6818

    Prednisolone

    Cortisol derivative; glucocorticoid agonist.

    ≥98%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • F4680

    Flutamide

    Non-steroid; AR antagonist.

    ≥98%
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only