LKT Labs

Biochemicals for Life Science Research

JZL184

Product ID J974440
Cas No. 1101854-58-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $49.70 In stock
10 mg $79.40 In stock
50 mg $314.30 In stock
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Description

JZL 184 is a monoacylglycerol lipase (MAGL) inhibitor. JZL 184 shows anti-nociceptive effects and reduces inflammation when administered in vivo to Sprague-Dawley rats. JZL 184 treatment in tandem with the fatty acid amide hydrolase (FAAH) inhibitor PF-3845 decreases withdrawal symptoms in opioid-dependent rodent models. It also shows anti-depressive effects in the chronic unpredictable mild stress mouse model for depression. In hepatocellular carcinoma (HCC), MAGL is upregulated. JZL 184 has been shown to limit the effects of MAGL in HCC, inhibiting the proliferation and invasion of HCC cells, and increasing apoptosis

Product Info

Cas No.

1101854-58-3
Purity

≥98%
Formula

C27H24N2O9
Formula Wt.

520.49
Chemical Name

4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
IUPAC Name

(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Synonym

JZL184, Monoacylglycerol Lipase (MAGL) Inhibitor III
Solubility

DMSO (>20 mg/mL)
Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

J974440 MSDS PDF
Info Sheet

J974440 Info Sheet PDF

References

Woodhams SG, Wong A, Barrett DA et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL 184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. Br J Pharmacol. 2012 Dec;167(8):1609-19. PMID: 22924700.

Ramesh D, Gamage TF, Vanuytsel T et al. Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice. Neuropsychopharmacology. 2013 May;38(6):1039-49. PMID: 23303065.

Zhong P, Wang W, Pan B et al. Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology. 2014 Jun;39(7):1763-76. PMID: 24476943.

Zhang J, Liu Z, Lian Z et al. Monoacylglycerol Lipase: A Novel Potential Thearpeutic Target and Prognostic Indicator for Hepatocellular Carcinoma. Sci Rep. 2016 Oct 21;6:35784. PMID 27767105.

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