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Ketorolac Tromethamine

Ketorolac Tromethamine

Product ID K1978
Cas No. 74103-07-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $50.50 In stock
5 g $188.70 In stock
25 g $754.60 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. Ketorolac inhibits COX-1 and COX-2. In vivo, administration of ketorolac prevents the spinal injury-induced increase of protease-activated receptor 1 (PAR1) levels and decreases activation of spinal astrocytes, resulting in decreased allodynia. In spinal neurons, ketorolac decreases substance P-, calcitonin gene-related peptide- and dynorphin-immunoreactivity. Additionally, this compound decreases expression of phosphodiesterase type 4 (PDE4D).

Product Info

Cas No.

74103-07-4

Purity

≥98%

Formula

C15H13NO3 • C4H11NO3

Formula Wt.

376.40

Chemical Name

2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

IUPAC Name

2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2, 3-dihydro-1H-pyrrolizine-1-carboxylic acid

Synonym

Toradol, Acular

Melting Point

165-167°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

K1978 MSDS PDF

Info Sheet

K1978 Info Sheet PDF

References

Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.

Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.

Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.

Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.

Custom Order

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