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L-5-hydroxytryptophan (L-5-HTP) is an endogenous amino acid precursor of 5-HT and melatonin that is commonly found in dietary supplements. L-5-HTP exhibits antidepressant and antioxidative activities. L-5-HTP acts as an antidepressant in clinical settings and shifts circadian rhythms in animal models. This compound also inhibits UV-induced apoptosis in monocytes.
| Cas No. | 4350-09-8 |
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| Purity | ≥98% |
| Formula | C11H12N2O3 |
| Formula Wt. | 220.22 |
| IUPAC Name | (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid |
| Synonym | L-5HTP, Oxitriptan, Cincofarm, Levothym, Oxyfann, Telestol |
| Melting Point | 270°C(dec) |
| Solubility | Slightly soluble in water. |
| Appearance | White to Gray FIne Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jangid P, Malik P, Singh P, et al. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr. 2013 Feb;6(1):29-34. PMID: 23380314.
Basu P, Singaravel M, Haldar C. L-5-hydroxytryptophan resets the circadian locomotor activity rhythm of the nocturnal Indian pygmy field mouse, Mus terricolor. Naturwissenschaften. 2012 Mar;99(3):233-9. PMID: 22331255.
Lysek N, Kinscherf R, Claus R, et al. L-5-Hydroxytryptophan: antioxidant and anti-apoptotic principle of the intertidal sponge Hymeniacidon heliophila. Z Naturforsch C. 2003 Jul-Aug;58(7-8):568-72. PMID: 12939046.