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L-Allylglycine is an inhibitor of glutamic acid decarboxylase (GAD). It is used to study a variety of topics in neuroscience, including attention and impulse control, fear, and anxiety. Allylglycine is used to induce seizures in animal models in order to study treatment-resistant seizure.
| Cas No. | 16338-48-0 |
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| Purity | ≥98% |
| Formula | C5H9NO2 |
| Formula Wt. | 115.13 |
| Chemical Name | L-Allylglycine |
| IUPAC Name | (2S)-2-aminopent-4-enoic acid |
| Synonym | (S)-2-aminopent-4-enoic acid,(S)-(-)-2-Amino-4-pentenoic acid, (S)-ALLYLGLYCINE |
| Solubility | Soluble in water-100 mg/mL. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Thomas J., Yang Y. Allylglycine-induced seizures in male and female rats. Physiol Behav. 49(6):1181-3 (1991). PMID: 1654571.
Paine T., Cooke E., et al. Effects of chronic inhibition of GABA synthesis on attention and impulse control. Pharmacol Biochem Behav. 135:97-104 (2015). PMID: 26044967.
Cunha J., Zanoveli J., et al. L-allylglycine dissociates the neural substrates of fear in the periaqueductal gray of rats. Brain Res Bull. 81(4-5):416-23 (2010). PMID: 19800953.
Leclercq K, Afrikanova T, Langlois M, et al. Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy Behav. 2015 Apr;45:53-63. PMID: 25845493.