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Letrozole

Letrozole

Product ID L1878
Cas No. 112809-51-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $75.10 In stock
25 mg $142.80 In stock
50 mg $225.40 In stock
100 mg $390.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Letrozole is an inhibitor of aromatase that prevents the formation of estrogens; it is clinically used to treat hormone-responsive breast cancer and infertility and to terminate pregnancy. Letrozole exhibits anticancer chemotherapeutic and anti-estrogenic activities. In vivo, letrozole increases secretion of luteinizing hormone (LH), lengthens the follicular dominance period, and delays subsequent follicular waves.

Product Info

Cas No.

112809-51-5

Purity

≥98%

Formula

C17H11N5

Formula Wt.

285.30

Chemical Name

4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

IUPAC Name

4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile

Synonym

Femara

Melting Point

181-183°C

Solubility

Soluble in dichloromethane, DMSO (100 mM). Slightly soluble in ethanol. practically insoluble in water. Soluble in chloroform, methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L1878 MSDS PDF

Info Sheet

L1878 Info Sheet PDF

References

Lee VC, Gao J, Lee KF, et al. The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta. Hum Reprod. 2013 Nov;28(11):2912-9. PMID: 23980056.

Tomao F, Spinelli G, Vici P, et al. Current role and safety profile of aromatase inhibitors in early breast cancer. Expert Rev Anticancer Ther. 2011 Aug;11(8):1253-63. PMID: 21916579.

Yapura J, Mapletoft RJ, Pierson R, et al. A bovine model for examining the effects of an aromatase inhibitor on ovarian function in women. Fertil Steril. 2011 Aug;96(2):434-438.e3. PMID: 21696721.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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