LKT Labs

Biochemicals for Life Science Research

Levamisole Hydrochloride

Levamisole Hydrochloride

Product ID L1682
Cas No. 16595-80-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $61.00 In stock
10 g $102.00 In stock
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Description

Levamisole is an imidazothiazole that exhibits immunomodulatory, anti-parasitic, anti-helminthic, anti-angiogenic, and anticancer chemotherapeutic activities. Levamisole inhibits alkaline phosphatase and may act as an agonist at nicotinic acetylcholine receptors (nAChRs). In multiple myeloma cells, levamisole induces DNA fragmentation, cytochrome c release and caspase 3 activation, inhibiting cellular proliferation. In other models, levamisole also inhibits proliferation and differentiation of endothelial cells and suppresses growth of various tumors in vivo.

Product Info

Cas No.

16595-80-5
Purity

≥98%
Formula

C11H12N2S • HCl
Formula Wt.

240.76
Chemical Name

Imidazo(2,1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (-)- (8CI)

IUPAC Name

(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1, 3]thiazole;hydrochloride
Synonym

Tetramisole hydrochloride, Citarin L, Ergamisol, Spartakon
Melting Point

228-230°C
Solubility

Soluble in water.

Appearance

A white or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L1682 MSDS PDF
Info Sheet

L1682 Info Sheet PDF

References

Ramanadham M, Nageshwari B. Anti-proliferative effect of levamisole on human myeloma cell lines in vitro. J Immunotoxicol. 2010 Oct-Dec;7(4):327-32. PMID: 20860474.

Friis T, Engel AM, Klein BM, et al. Levamisole inhibits angiogenesis in vitro and tumor growth in vivo. Angiogenesis. 2005;8(1):25-34. PMID: 16132615.

Zinser EW, Wolf ML, Alexander-Bowman SJ, et al. Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. J Vet Pharmacol Ther. 2002 Aug;25(4):241-50. PMID: 12213111.

Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. PMID: 6169.

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