LKT Labs

Biochemicals for Life Science Research

Limonin Glucoside

Product ID L3551
Cas No. 123564-61-4
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $166.80 In stock
5 mg $584.30 In stock
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Description

Limonin is a furanolactone found in fruits in the Citrus family. Limonin exhibits antioxidative, anti-inflammatory, hepatoprotective, anticancer, antiviral, anti-parasitic, and immunomodulatory activities. In animal models of hepatic ischemia/reperfusion, limonin upregulates expression of IL-10 and downregulates expression of toll-like receptors 2 and 4 (TLR2, TLR4), MyD88, TRIF, TNF-α, and NF-κB. In colon adenocarcinoma cells, limonin induces mitochondria-dependent apoptosis and inhibits proliferation. Additionally, limonin inhibits expression of HIV-1 and HTLV-1 in infected cells. This compound also exhibits larvicidal activity against species of Aedes and decreases NF-κB activation and CD4+ T cell stimulation in vitro.

Product Info

Cas No.

123564-61-4
Purity

≥95%
Formula

C32H42O14
Formula Wt.

650.67
IUPAC Name

(3'S,4aS,6aR,8aR,9R,10S,12aR,12bR)-10-[(S)-3-Furyl(β-D-glucopyranosyloxy)methyl]-6,6,8a,10-tetramethyl-3,8-dioxodecahydro-3H,6H-spiro[naphtho[1',2':3,4]furo[3,2-c]pyran-9,2'-oxirane]-3'-carboxylic acid
Synonym

Limonin 17 β-D-glucopyranoside

Solubility

Soluble in methanol, water (5 mg/mL).

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

L3551 MSDS PDF
Info Sheet

L3551 Info Sheet PDF

References

Mahmoud MF, Gamal S, El-Fayoumi HM. Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway. Eur J Pharmacol. 2014 Jun 23. [Epub ahead of print]. PMID: 24967531.

Hafeez F, Akram W, Shaalan EA. Mosquito larvicidal activity of citrus limonoids against Aedes albopictus. Parasitol Res. 2011 Jul;109(1):221-9. PMID: 21212981.

Chidambara Murthy KN, Jayaprakasha GK, et al. Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis. J Agric Food Chem. 2011 Mar 23;59(6):2314-23. PMID: 21338095.

Balestrieri E, Pizzimenti F, Ferlazzo A, et al. Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. Bioorg Med Chem. 2011 Mar 15;19(6):2084-9. PMID: 21334901.

Kim W, Fan YY, Smith R, et al. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J Nutr. 2009 May;139(5):1042-8. PMID: 19321585.

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