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γ-Linolenic Acid (6c, 9c, 12c)

γ-Linolenic Acid (6c, 9c, 12c)

Product ID L3456
Cas No. 506-26-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $98.00 Please Inquire
25 mg $173.70 Please Inquire
100 mg $510.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

γ-Linolenic acid (GLA) is an omega-6 fatty acid typically found in vegetable oils that exhibits antithrombotic, anti-inflammatory, and anti-atherosclerotic properties. GLA is a precursor to prostaglandin E1 and eicosapentaenoic acid. This compound regulates insulin secretion through its natural agonist activity at peroxisome proliferator-activated receptors (PPARs); it inhibits diabetes mellitus-induced albuminuria and increases in MCP-1. GLA may also have anticancer activity, as it alters generation of ROS, decreases production of TNF-α, and induces apoptosis in leukemia cells.

 

Product Info

Cas No.

506-26-3

Purity

≥98%

Formula

C18H30O2

Formula Wt.

278.43

IUPAC Name

(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid

Synonym

gamma-Linolenic acid, cis,cis,cis-6,9,12-Octadecatrienoic acid, GLA

Solubility

Soluble in methanol, ethanol, ethyl acetate. Slightly soluble in chloroform.

Appearance

Clear liquid/white solid

Shipping and Storage

Store Temp

-80°C

Ship Temp

Ambient

Downloads

MSDS

L3456 MSDS PDF

Info Sheet

L3456 Info Sheet PDF

References

Lai MC, Teng TH, Yang C. The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in Rat Pancreas. J Vet Med Sci. 2013 Jul 5. [Epub ahead of print] PMID: 23832628.

Kim DH, Yoo TH, Lee SH, et al. Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. Yonsei Med J. 2012 Nov 1;53(6):1165-75. PMID: 23074118.

Das UN. Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives. Curr Pharm Biotechnol. 2006 Dec;7(6):457-66. PMID: 17168663.

Kong X, Ge H, Hou L, et al. Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3. Chem Biol Interact. 2006 Aug 25;162(2):140-8. PMID: 16857180.

Jung KC, Park CH, Hwang YH, et al. Fatty acids, inhibitors for the DNA binding of c-Myc/Max dimer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell. Leukemia. 2006 Jan;20(1):122-7. PMID: 16281068.

Andreassi M, Forleo P, Di Lorio A, et al. Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. J Int Med Res. 1997 Sep-Oct;25(5):266-74. PMID: 9364289.

Custom Order

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