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Mastoparan X

Mastoparan X

Product ID M0173
Cas No. 72093-22-2
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $98.40 In stock
2 mg $167.80 In stock
5 mg $294.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mastoparan X is an antimicrobial/antibacterial peptide (AMP) derived from the venom of bees and wasps. Mastoparan X activates mast cells through binding and activation of the Gα subunit of GPCRs. Mastoparan X enters into neutral and negatively charged membranes, causing formation and leakage of giant unilamellar vesicles and inducing barrier disruptions.

Product Info

Cas No.

72093-22-2

Purity

≥95%

Formula

C73H126N20O15S

Formula Wt.

1556.01

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-6-amino-1-[[2-[[(3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]butanediamide

Synonym

Mast cell degranulating peptide (Vespa xanthoptera) (9CI)

Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M0173 MSDS PDF

Info Sheet

M0173 Info Sheet PDF

References

dos Santos LD, Aparecido dos Santos Pinto JR, Menegasso AR, et al. Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells. Proteomics. 2012 Aug;12(17):2682-93. PMID: 22761183.

Cabrera MP, Alvares DS, Leite NB, et al. New insight into the mechanism of action of wasp mastoparan peptides: lytic activity and clustering observed with giant vesicles. Langmuir. 2011 Sep 6;27(17):10805-13. PMID: 21797216.

Etzerodt T, Henriksen JR, Rasmussen P, et al. Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. Biophys J. 2011 Jan 19;100(2):399-409. PMID: 21244836.

Todokoro Y, Yumen I, Fukushima K, et al. Structure of tightly membrane-bound mastoparan-X, a G-protein-activating peptide, determined by solid-state NMR. Biophys J. 2006 Aug 15;91(4):1368-79. PMID: 16714348.

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