LKT Labs

Biochemicals for Life Science Research

Mefenamic Acid

Mefenamic Acid

Product ID M1622
Cas No. 61-68-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $41.00 In stock
50 g $71.50 In stock
100 g $102.00 In stock
Bulk Quote

Quicklinks

Description

Mefenamic acid is a fenamate non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, neuroprotective, anticancer, and neuromodulatory activities. Mefenamic acid is a non-selective inhibitor of COX-1 and COX-2 that also potentiates activity at GABA-A receptors. In animal models of cerebral ischemia, mefenamic acid decreases infarct volume, edema, and ischemic brain damage. Additionally, this compound inhibits proliferation in colon cancer cells by altering cell cycle regulators and inhibiting store-operated Ca2+ entry into cells.

Product Info

Cas No.

61-68-7
Purity

≥98%
Formula

C15H15NO2
Formula Wt.

241.29
Chemical Name

2-[(2,3-Dimethylphenyl)amino]benzoic acid
IUPAC Name

2-(2,3-dimethylanilino)benzoic acid
Synonym

Bonabol, Coslan, Lysalgo, Mefenacid, Ponstel, Tanston
Melting Point

230-231°C
Solubility

Insoluble in water. Sparingly soluble in ether and chloroform. Soluble in alkali hydroxide solutions.

Appearance

White Micro-Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M1622 MSDS PDF
Info Sheet

M1622 Info Sheet PDF

References

Khansari PS, Halliwell RF. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int. 2009 Dec;55(7):683-8. PMID: 19563851.

Weiss H, Amberger A, Widschwendter M, et al. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer. 2001 Jun 15;92(6):877-82. PMID: 11351310.

Halliwell RF, Thomas P, Patten D, et al. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. Eur J Neurosci. 1999 Aug;11(8):2897-905. PMID: 10457186.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4556

    Florfenicol

    Synthetic fluorinated thiamphenicol analog; pro...

    ≥98%
  • M185770

    5-Methyltetrahydrofolic Acid

    Folic acid derivative

    ≥98%
  • F5868

    Formoterol Fumarate Dihydrate

    β2-adrenergic agonist.

    ≥98%
  • V0160

    Vapreotide

    Synthetic somatostatin analog, peptide; somatos...

    ≥95%
  • A5034

    4-Aminosalicylic Sodium Dihydrate

    Dihydrofolate reductase inhibitor.

    ≥98%
  • P6857

    Protocatechuic Acid

    Polyphenol found in many plants and foods.

    ≥97%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • T7132

    Triacetyl Resveratrol

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • G4781

    Glucoraphanin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • M3379

    Mitoxantrone Dihydrochloride

    Anthracenedione, DNA intercalator; Pim-1 inhibi...

    ≥98%
  • A0778

    ABT-737

    BH3 mimetic; Bcl-2, Bxl-xl, Bcl-w inhibitor.

    ≥98%
  • S0831

    S-(−)-Schisandrin B

    Found in Schisandra.

    ≥98%
  • C324091

    Ciclesonide

    Corticosteroid

    ≥98%
  • M185777

    4-(Methylsulfinyl) butylamine

    ≥99%
  • V1854

    Venlafaxine Hydrochloride

    SERT, NET, MAO inhibitor.

    ≥98%
  • M3377

    Mitomycin C

    Alkaloid produced by Streptomyces, DNA cross-li...

    ≥98%
  • A0819

    Acetylsalicylic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • M1976

    Methimazole

    Thioamide; thyroid peroxidase inhibitor.

    ≥98%
  • C1637

    Ceftriaxone Disodium Hemiheptahydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥98%
  • M3577

    Mitiglinide Calcium

    ATP-sensitive K+ channel blocker, potential RyR...

    ≥98%