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Monensin is a polyether antibiotic initially produced by Streptomyces that exhibits antibactieral and anti-parasitic activities. Monensin is commercially used in cattle feed; it acts as an ionophore, transporting cations across cell membranes. Monensin inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.
| Cas No. | 22373-78-0 |
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| Purity | ≥98% |
| Formula | C36H61O11 Na |
| Formula Wt. | 692.86 |
| Chemical Name | 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetra- hydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl- 2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β- methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]- decane-7-butyric acid sodium salt |
| IUPAC Name | sodium;(2R,3S,4R)-4-[(2R,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2S,3R, 5S)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3, 5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2, 8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate |
| Synonym | Monensin sodium salt, Coban, Romemsin, Rumensin |
| Melting Point | 267-269°C |
| Solubility | Insoluble in water. Soluble in DMSO, ethanol, methanol, chloroform, other organic solvents. |
| Appearance | A White or Almost White Crystalline Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Choi HS, Jeong EH, Lee TG, et al. Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells. Tuberc Respir Dis (Seoul). 2013 Jul;75(1):9-17. PMID: 23946753.
Lavine MD, Arrizabalaga G. Analysis of monensin sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death. PLoS One. 2012;7(7):e42107. PMID: 22848721.