• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Neurokinin B

Neurokinin B

Product ID N1978
Cas No. 86933-75-7
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
2 mg $89.30 Please Inquire
5 mg $157.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Neurokinin B is an endogenous neuromodulatory peptide that binds the neurokinin 3 (NK3) receptor and is co-expressed with kisspeptin and dynorphin A. Neurokinin B increases osteoclast activity and bone resorption in vitro and induces contraction in ileal smooth muscle cells. Neurokinin B also exhibits neuroprotective activity, decreasing toxic effects of amyloid-β (Aβ) by increasing superoxide dismutase (SOD) activity, decreasing monoamine oxidase (MAO) activity, and restoring intracellular Ca2+ levels. Neurokinin B may also be used as a biomarker for pregnancy-induced hypertension and pre-eclampsia.

Product Info

Cas No.

86933-75-7

Purity

≥95%

Formula

C55H79N13O14S2

Formula Wt.

1210.45

IUPAC Name

3-amino-4-[[1-[[1-[[1-[[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid

Synonym

Neurokinin K

Solubility

Soluble in water (0.8 mg/mL), ammonium hydroxide.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N1978 MSDS PDF

Info Sheet

N1978 Info Sheet PDF

References

Ichiki T, Kuroishi KN, Gunjigake KK, et al. Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides. 2011 Jun;45(3):239-44. PMID: 21514667

Mantha AK, Moorthy K, Cowsik SM, et al. Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity. Biogerontology. 2006 Feb;7(1):1-17. PMID: 16518716.

Page NM, Woods RJ, Gardiner SM, et al. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000 Jun 15;405(6788):797-800. PMID: 10866201.

Suzuki N, Mizuno K, Gomi Y. Tachykinin-induced contractions in the circular muscle of guinea pig ileum. Jpn J Pharmacol. 1994 Jul;65(3):233-40. PMID: 7528285.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P6954

    Pioglitazone Hydrochloride

    Thiazolidinedione; PPARα/γ agonist, mitoNEET ...

    ≥98%
  • G4535

    Glimepiride

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • U6857

    Urodilatin CCC

    ANP fragment, natriuretic peptide; Na+/K+ ATPas...

    ≥98%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • M3196

    MHY-1485

    mTOR activator.

    ≥98%
  • G3252

    6-Gingerol

    Phenol found in Zingiber; TRPV1 agonist, 5-HT3 ...

    ≥98%
  • T1024

    Baccatin VI

    Fermentation impurity

    ≥98%
  • T5870

    Torin 1

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • G0096

    GAY

    Tripeptide, used to tag proteins.

    ≥95%
  • C0800

    C59

    PORCN inhibitor.

    ≥98%
  • T3099

    Thymus Factor

    Endogenous peptide, involved in immune signalin...

    ≥95%
  • I0801

    IC261

    Casein kinase 1 inhibitor.

    ≥98%
  • R5992

    Roxithromycin

    Macrolide; protein synthesis inhibitor.

    ≥96%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • N3276

    Nitroso(acetoxymethyl)methylamine

    NNK precursor found in tobacco smoke; carcinoge...

    ≥97%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • D5747

    Dolasetron Mesylate Hydrate

    5-HT3 antagonist.

    ≥98%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only