Neurokinin B

Name: Neurokinin B
SKU: N1978
Availability: InStock

Product ID N1978

Cas No. 86933-75-7

Purity ≥95%

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Description

Neurokinin B is an endogenous neuromodulatory peptide that binds the neurokinin 3 (NK3) receptor and is co-expressed with kisspeptin and dynorphin A. Neurokinin B increases osteoclast activity and bone resorption in vitro and induces contraction in ileal smooth muscle cells. Neurokinin B also exhibits neuroprotective activity, decreasing toxic effects of amyloid-β (Aβ) by increasing superoxide dismutase (SOD) activity, decreasing monoamine oxidase (MAO) activity, and restoring intracellular Ca2+ levels. Neurokinin B may also be used as a biomarker for pregnancy-induced hypertension and pre-eclampsia.

Product Info

Cas No.	86933-75-7
Purity	≥95%
Formula	C₅₅H₇₉N₁₃O₁₄S₂
Formula Wt.	1210.45
IUPAC Name	3-amino-4-[[1-[[1-[[1-[[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Synonym	Neurokinin K
Solubility	Soluble in water (0.8 mg/mL), ammonium hydroxide.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

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MSDS	N1978 MSDS PDF
Info Sheet	N1978 Info Sheet PDF

References

Ichiki T, Kuroishi KN, Gunjigake KK, et al. Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides. 2011 Jun;45(3):239-44. PMID: 21514667

Mantha AK, Moorthy K, Cowsik SM, et al. Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity. Biogerontology. 2006 Feb;7(1):1-17. PMID: 16518716.

Page NM, Woods RJ, Gardiner SM, et al. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000 Jun 15;405(6788):797-800. PMID: 10866201.

Suzuki N, Mizuno K, Gomi Y. Tachykinin-induced contractions in the circular muscle of guinea pig ileum. Jpn J Pharmacol. 1994 Jul;65(3):233-40. PMID: 7528285.

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Neurokinin B

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