Neurokinin B

Name: Neurokinin B
SKU: N1978
Availability: InStock

Product ID N1978

Cas No. 86933-75-7

Purity ≥95%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Neurokinin B is an endogenous neuromodulatory peptide that binds the neurokinin 3 (NK3) receptor and is co-expressed with kisspeptin and dynorphin A. Neurokinin B increases osteoclast activity and bone resorption in vitro and induces contraction in ileal smooth muscle cells. Neurokinin B also exhibits neuroprotective activity, decreasing toxic effects of amyloid-β (Aβ) by increasing superoxide dismutase (SOD) activity, decreasing monoamine oxidase (MAO) activity, and restoring intracellular Ca2+ levels. Neurokinin B may also be used as a biomarker for pregnancy-induced hypertension and pre-eclampsia.

Product Info

Cas No.	86933-75-7
Purity	≥95%
Formula	C₅₅H₇₉N₁₃O₁₄S₂
Formula Wt.	1210.45
IUPAC Name	3-amino-4-[[1-[[1-[[1-[[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Synonym	Neurokinin K
Solubility	Soluble in water (0.8 mg/mL), ammonium hydroxide.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N1978 MSDS PDF
Info Sheet	N1978 Info Sheet PDF

References

Ichiki T, Kuroishi KN, Gunjigake KK, et al. Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. Neuropeptides. 2011 Jun;45(3):239-44. PMID: 21514667

Mantha AK, Moorthy K, Cowsik SM, et al. Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity. Biogerontology. 2006 Feb;7(1):1-17. PMID: 16518716.

Page NM, Woods RJ, Gardiner SM, et al. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. Nature. 2000 Jun 15;405(6788):797-800. PMID: 10866201.

Suzuki N, Mizuno K, Gomi Y. Tachykinin-induced contractions in the circular muscle of guinea pig ileum. Jpn J Pharmacol. 1994 Jul;65(3):233-40. PMID: 7528285.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Neurokinin B

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Penciclovir

CV-70

SRT1720 Hydrochloride

Tropisetron Hydrochloride

Perillyl Alcohol

1-Isothiocyanato-8-(methylsulfonyl)-octane

Blasticidin S Hydrochloride

Tetrahydroberberine

Epigallocatechin Gallate

Valiltramiprosate

Abemaciclib mesylate

Clindamycin Phosphate

Abamectin

AZD-7762

2-Hydroxyestradiol

Bis(3,5-dibromosalicyl) Fumarate

Bakuchiol

Spiramycin Hexanedioate

Dextromethorphan Hydrobromide Hydrate

Torin 1

Footer