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Nisoldipine

Nisoldipine

Product ID N3474
Cas No. 63675-72-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $57.80 In stock
50 mg $78.80 In stock
250 mg $102.90 In stock
1 g $152.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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Description

Nisoldipine is an L-type Ca2+ channel blocker which with long-term treatment can prevent the development of hypertension and cardiac hypertrophy in young spontaneously hypertensive rats. It is a dihydropyridine analog that acts as an activator of the human pregnane X receptor, which in turn mediates activation of gene sets involved in the metabolism of xenobiotics.

Product Info

Cas No.

63675-72-9

Purity

≥98%

Formula

C20H24N2O6

Formula Wt.

388.42

Chemical Name

3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

IUPAC Name

Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Synonym

Sular, Nisocor, Zadipina

Solubility

Soluble in DMSO to 100 mM and in ethanol to 100 mM

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N3474 MSDS PDF

Info Sheet

N3474 Info Sheet PDF

References

Missan S, Zhabyeyev P, Dyachok O, et al. Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov; 140(5): 863-870. PMID: 14530219.

Stasch J, Kazda S, Hirth C, et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension. 1987 Sep; 10(3): 303-307. PMID: 2957322.

Pan Y, Li L, Kim G, et al. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening. Drug Metab Dispos. 2011 Feb; 39(2): 337-344. PMID: 21068194.

Custom Order

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