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NS-11394

NS-11394

Product ID N7200
Cas No. 951650-22-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $245.10 In stock
25 mg $844.10 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NS-11394 is a positive modulator of GABA-A receptor activity that is somewhat specific for α5/3/2 subunits. This compound exhibits analgesic and anxiolytic activities. In vivo, NS-11394 decreases formalin-induced pain and spinal nerve-ligation-induced mechanical allodynia. NS-11394 also decreases anxiety in animal models, but its use is dose-limited by side effects that include memory impairment.

Product Info

Cas No.

951650-22-9

Purity

≥98%

Formula

C23H19N3O

Formula Wt.

353.43

Chemical Name

3'-[5-(2-Hydroxy-2-propanyl)-1H-benzimidazol-1-yl]-2-biphenylcarbonitrile

IUPAC Name

2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile

Synonym

NS11394; UNII-1PTH9FK74J; NS 11394; 1PTH9FK74J

Solubility

DMSO:43mg/ml

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N7200 MSDS PDF

Info Sheet

N7200 Info Sheet PDF

References

Hofmann M, Kordás KS, Gravius A, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behav Pharmacol. 2012 Dec;23(8):790-801. Erratum in: Behav Pharmacol. 2013 Apr;24(2):153. PMID: 23075708.

Hansen RR, Erichsen HK, Brown DT, et al. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats. Neuropharmacology. 2012 Dec;63(8):1360-7. PMID: 22985969.

Mirza NR, Larsen JS, Mathiasen C, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68. PMID: 18791063.

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