| Product Unit Size | Cost | Quantity | Stock |
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NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction.
| Cas No. | 1448867-41-1 |
|---|---|
| Purity | ≥99% |
| Formula | C26H24Cl2N6O4 |
| Formula Wt. | 555.41 |
| IUPAC Name | (4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one |
| Synonym | Siremadlin; HDM-201 |
| Appearance | White crystalline powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Wu C, Huang C, Chen C, et al. WIP1 inhibition by GSK2830371 potentiates HDM201 through enhanced p53 phosphorylation and activation in liver adenocarcinoma cells. Cancers (Basel). 2021 Jul 31;13(15):3876. PMID: 34359777
Wang H, Mulford I, Sharp F, et al. Inhibition of MDM2 promotes antitumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Res. 2021 Jun 1;81(11):3079-3091. PMID: 33504557
Vaupel A, Holzer P, Ferretti S, et al. In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3404-3408. PMID: 30217415