Description
NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction.
Product Unit Size | Cost | Quantity | Stock |
---|
NVP-HDM201 is a selective inhibitor of the MDM2-p53 interaction.
Cas No. | 1448867-41-1 |
---|---|
Purity | ≥99% |
Formula | C26H24Cl2N6O4 |
IUPAC Name | (4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one |
Synonym | Siremadlin; HDM-201 |
Appearance | White crystalline powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Wu C, Huang C, Chen C, et al. WIP1 inhibition by GSK2830371 potentiates HDM201 through enhanced p53 phosphorylation and activation in liver adenocarcinoma cells. Cancers (Basel). 2021 Jul 31;13(15):3876. PMID: 34359777
Wang H, Mulford I, Sharp F, et al. Inhibition of MDM2 promotes antitumor responses in p53 wild-type cancer cells through their interaction with the immune and stromal microenvironment. Cancer Res. 2021 Jun 1;81(11):3079-3091. PMID: 33504557
Vaupel A, Holzer P, Ferretti S, et al. In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3404-3408. PMID: 30217415
ATM and ATR inhibitor.
FIASMA, histamine H1 inverse agonist, 5-HT2A, D...
Taxane found in Taxus; microtubule depolymeriza...
Thienylbutyl ITC analog.
Cyclic peptide; calcineurin inhibitor.
Retinoid, differentiation inducer.
Triterpenoid found in Vigna angularis and Trigo...
Coccidiostat, GAPDH inhibitor.
Semi-synthetic taxane.
K+ channel blocker, catecholamine release stimu...
Rapamycin analog
Polyphenol found in Camilla sinensis; HIV integ...
Synthetic ITC.
Polymixin, antimicrobial peptide, induces forma...
B-Raf and c-Raf inhibitor.
ROCK inhibitor.
ALK5 (activin-like) inhibitor.
Mast cell stabilizer; histamine H1/2/3 antagoni...
EGFR inhibitor.
Tyrosine kinase inhibitor.