• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
NVP-LDE225

NVP-LDE225

Product ID N859614
Cas No. 956697-53-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 In stock
10 mg $300.40 In stock
25 mg $601.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-LDE225 is an inhibitor of Smo that prevents hedgehog (Hh) signaling; it exhibits anticancer chemotherapeutic and anti-metastatic activities. NVP-LDE225 is currently approved for the treatment of basal cell carcinoma but is also in clinical trials as a potential treatment for other cancers. In renal cell carcinoma cells, NVP-LDE225 inhibits cellular proliferation, migration, and invasion; in animal models, it increases survival rates and decreases tumor growth. NVP-LDE225 also inhibits cell viability in prostate cancer cells. In animal models of prostate cancer, this compound inhibits the epithelial-to-mesenchymal transition (EMT), induces apoptosis, decreases the expression of Bcl-2, Bcl-xl, XIAP, and survivin, and increases the expression of Bax and Bak; it also inhibits tumor growth. Smo antagonists such as NVP-LDE225 also cause alopecia, likely due to alteration in hair follicle embryology.

Product Info

Cas No.

956697-53-3

Purity

≥98%

Formula

C26H26F3N3O3

Formula Wt.

485.51

Chemical Name

N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

IUPAC Name

N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

Synonym

Erismodegib, Sonidegib, LDE225

Solubility

DMSO:97 mg/mL (199.79 mM) Ethanol:97 mg/mL warmed (199.79 mM) Water insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N859614 MSDS PDF

Info Sheet

N859614 Info Sheet PDF

References

Ferguson J, Hannam S, Toholka R, et al. Hair Loss and Hedgehog Inhibitors - A Class Effect? Br J Dermatol. 2014 Dec 18. [Epub ahead of print]. PMID: 25523648.

D'Amato C, Rosa R, Marciano R, et al. Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells. Br J Cancer. 2014 Sep 9;111(6):1168-79. PMID: 25093491.

Nanta R, Kumar D, Meeker D, et al. NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128. Oncogenesis. 2013 Apr 8;2:e42. PMID: 23567619.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G124084

    GDC-0973

    MEK1 inhibitor.

    ≥99%
  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%
  • Y1000

    Y27632 Dihydrochloride

    ROCK inhibitor.  
    ≥99%
  • G8850

    GW-5074

    c-Raf inhibitor.

    ≥98%
  • O4532

    Oligomycin B

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • P1849

    Pemetrexed Disodium

    Thymidylate synthase inhibitor, potential SHMT,...

    ≥98%
  • C211324

    CFI-400945

    PLK4 inhibitor.

    ≥98%
  • M3344

    Milrinone

    PDE3 inhibitor.

    ≥98%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • P1761

    Pepstatin

    Aspartyl protease inhibitor.

    ≥98%
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • D1776

    Desmopressin

    Synthetic vasopressin derivative; V2R agonist.<...

    ≥95%
  • T1025

    D-Seco Paclitaxel

    D-Seco Paclitaxel is an impurity in the product...

    ≥90%
  • C3446

    Cilnidipine

    Dihydropyridine; L-type and N-type Ca2+ channel...

    ≥98%
  • C9613

    Cyclosporin D

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • S0929

    SCH-772984

    ERK1/2 inhibitor.

    ≥97%
  • A851322

    Avibactam Sodium

    Diazabicyclooctane β-lactamase inhibitor.

    ≥98%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only