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Olsalazine Sodium

Olsalazine Sodium

Product ID O4672
Cas No. 6054-98-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $281.60 In stock
250 mg $563.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olsalazine is a prodrug of 5-aminosalicylate that exhibits anti-inflammatory and chemopreventive activities. Olsalazine is used in both human and veterinary medicine and most commonly treats ulcerative colitis. Olsalazine acts as a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2. In colonic epithelial cells, this compound prevents binding of IFN-γ to its receptor and, in other cellular models, inhibits activity of myeloperoxidase. In subjects with ulcerative colitis, olsalazine decreases risk of dysplasia and colorectal cancer.

Product Info

Cas No.

6054-98-4

Purity

≥98%

Formula

C14H8N2O6Na2

Formula Wt.

346.2

IUPAC Name

disodium;5-[2-(3-carboxy-4-oxocyclohexa-2, 5-dien-1-ylidene)hydrazinyl]-2-oxidobenzoate

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O4672 MSDS PDF

Info Sheet

O4672 Info Sheet PDF

References

Malewska K, Rychlik A, Nieradka R, et al. Treatment of inflammatory bowel disease (IBD) in dogs and cats. Pol J Vet Sci. 2011;14(1):165-71. PMID: 21528730.

Rubin DT, LoSavio A, Yadron N, et al. Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis. Clin Gastroenterol Hepatol. 2006 Nov;4(11):1346-50. PMID: 17059900.

Crotty B, Rosenberg WM, Aronson JK, et al. Inhibition of binding of interferon-gamma to its receptor by salicylates used in inflammatory bowel disease. Gut. 1992 Oct;33(10):1353-7. PMID: 1446859.

Kettle AJ, Winterbourn CC. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol. 1991 May 15;41(10):1485-92. PMID: 1850278.

Custom Order

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