• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Paclitaxel, from Taxus yunnanensis

Paclitaxel, from Taxus yunnanensis

Product ID P0092
Cas No. 33069-62-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $56.50 In stock
5 mg $98.60 In stock
25 mg $225.30 In stock
100 mg $507.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Paclitaxel is a diterpene compound found in Taxus yunnanensis that exhibits anticancer chemotherapeutic and anti-angiogenic activities. Paclitaxel induces tubulin polymerization, forming stable but nonfunctional microtubules; it inhibits shortening of microtubule leading edges, decreases peripheral microtubule formation, and alters morphology of focal adhesions, preventing cell migration and proliferation. Paclitaxel also dysregulates the epithelial-to-mesenchymal (EMT) transition, inducing transition of cancer cells into benign fibroblast-like cells. In vitro, paclitaxel induces caspase 8-mediated apoptosis through the association of caspase 8’s death effector domain with microtubules.

 

Product Info

Cas No.

33069-62-4

Purity

≥98%

Formula

C47H51NO14

Formula Wt.

853.91

Chemical Name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

IUPAC Name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Synonym

Taxol, Taxol A, Paxene

Melting Point

213-217°C

Solubility

Insoluble in water (4 mg/L). Soluble in ethanol (18 mg/mL), DMSO (50 mg/mL).

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P0092 MSDS PDF

Info Sheet

P0092 Info Sheet PDF

References

Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616.

Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • V0147

    Valproic Acid Sodium

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • S1970

    Serum Thymic Factor

    Synthetic peptide hormone.

    ≥95%
  • N3496

    Nizatidine

    Histamine H2 inverse agonist.

    ≥98%
  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • G1749

    Gemfibrozil

    Fibrate; PPARα agonist, enoyl-CoA reductase in...

    ≥98%
  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • V0369

    Varenicline Tartrate

    α7 and β4 nAChR agonist, α4β2 and α6β2 nA...

    ≥99%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • X0254

    Xanthohumol

    Prenylated flavonoid found in Humulus lupulus.<...

    ≥98%
  • A1218

    Adefovir Dipivoxil

    Acyclic nucleotide (adenosine) analog, adefovir...

    ≥98%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • V5886

    Voriconazole

    Triazole; 14α demethylase inhibitor.

    ≥98%
  • B5561

    B-type Natriuretic Peptide (1-32), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥97%
  • A6978

    Artemisinin

    Sesquiterpene lactone found in Artemisia (wormw...

    ≥98%
  • C760001

    CT-7001

    CDK7 inhibitor

    ≥99%
  • A4438

    Allatostatin I

    Neuropeptide found in insects; juvenile hormone...

    ≥95%
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only