Description
PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.
| Product Unit Size | Cost | Quantity | Stock |
|---|
PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.
| Cas No. | 1844849-10-0 |
|---|---|
| Purity | ≥99% |
| Formula | C22H24Cl2N2O5 |
| Formula Wt. | 467.34 |
| IUPAC Name | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one |
| Synonym | PF06821497 |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
|---|
Zhang Y, Zhou L, Safran H, et al. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia. 2021 Aug;23(8):792-810. PMID: 34246076
Yamazaki S, Gukasyan H, Wang H, et al. Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of epigenetic regulator enhancer of zeste homolog 2. J Pharmacol Exp Ther. 2020 May;373(2):220-229. PMID: 32094296
p110δ PI3K inhibitor.
Peptide, GLP-1 analog found in Heloderma; GLP-1...
Natural antibiotic found in Streptomyces parvul...
Endogenous peptide fragment, involved in vasoco...
Triazole; demethylation inhibitor.
Bosutinib isomer; Src and Abl inhibitor.
Cembranoid diterpene found in Sarcophyton glauc...
Imidazole; 14-α demethylase inhibitor.
Nitrogen mustard and estradiol derivative; micr...
Peptide found in molluscs, cardiomodulator.
Synthesis intermediate
Cyclic hexapeptide isolated from Phomopsis lept...
Smo inhibitor.
Mixture of quaternary ammonium salts, cationic ...
Pentacyclic triterpene found in the Banaba plan...
Organosulfur found in garlic.
Tenoxicam impurity
FGFR inhibitor.
5-Nitroimidazole derivative; genotoxic.
Mixture of kavalactones found in Piper methysti...