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PF-06821497

PF-06821497

Product ID P200097
Cas No. 1844849-10-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $105.00 In stock
5 mg $215.00 In stock
10 mg $358.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.

Product Info

Cas No.

1844849-10-0

Purity

≥99%

Formula

C22H24Cl2N2O5

Formula Wt.

467.34

IUPAC Name

5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one

Synonym

PF06821497

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

P200097 Info Sheet PDF

References

Zhang Y, Zhou L, Safran H, et al. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia. 2021 Aug;23(8):792-810. PMID: 34246076

Yamazaki S, Gukasyan H, Wang H, et al. Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of epigenetic regulator enhancer of zeste homolog 2. J Pharmacol Exp Ther. 2020 May;373(2):220-229. PMID: 32094296

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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