Description
PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.
Product Unit Size | Cost | Quantity | Stock |
---|
PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.
Cas No. | 1844849-10-0 |
---|---|
Purity | ≥99% |
Formula | C22H24Cl2N2O5 |
Formula Wt. | 467.34 |
IUPAC Name | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one |
Synonym | PF06821497 |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Zhang Y, Zhou L, Safran H, et al. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia. 2021 Aug;23(8):792-810. PMID: 34246076
Yamazaki S, Gukasyan H, Wang H, et al. Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of epigenetic regulator enhancer of zeste homolog 2. J Pharmacol Exp Ther. 2020 May;373(2):220-229. PMID: 32094296
Semi-synthetic diterpene originally found in Ta...
L-type and T-type Ca2+ and TRP antagonist.
β-lactam cephalosporin; penicillin binding pro...
Triazole; gibberellin inhibitor, potential 14-Î...
Mycotoxin produced by Fusarium; sphingosine acy...
Podophyllotoxin derivative; topoisomerase II in...
Tretinoin analog; RARα/β/γ agonist.
Used for in vitro fertilization; FIASMA, SERM.<...
RXR agonist.
Synthetic vasopressin derivative; V2R agonist.<...
Carnitine derivative, involved in energy homeos...
Trichothecene mycotoxin produced by Fusarium.
SERM, androgen modulator.
Selective inhibitor of c-Met.
Naphthalene; indirect STAT1 agonist.
TRPC5, NS4B, histamine H1 inhibitor.
An omega-3 fatty acid.
Histamine H2 antagonist.
Endogenous neuropeptide, involved in energy hom...
Sulfonylurea; ATP-sensitive K+ channel blocker....