Description
PF-06821497 is an inhibitor of EZH2 showing antiproliferation and antitumor effects in diffuse large B-cell lymphoma cell model.
PF-06821497
Product ID P200097
Cas No. 1844849-10-0
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1844849-10-0 |
|---|---|
| Purity | ≥99% |
| Formula | C22H24Cl2N2O5 |
| Formula Wt. | 467.34 |
| IUPAC Name | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one |
| Synonym | PF06821497 |
| Appearance | White powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Zhang Y, Zhou L, Safran H, et al. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia. 2021 Aug;23(8):792-810. PMID: 34246076
Yamazaki S, Gukasyan H, Wang H, et al. Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of epigenetic regulator enhancer of zeste homolog 2. J Pharmacol Exp Ther. 2020 May;373(2):220-229. PMID: 32094296