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Phenylethyl 3-methylcaffeate exhibits anticancer chemotherapeutic and chemopreventive activities. Phenylethyl-3-methylcaffeate is a hydroxycinnamic acid and derivative of methylcaffeate. This compound decreases the incidence, number, and volume of tumors in various animal models. Additionally, this compound induces apoptosis and inhibits carcinogenesis in animal models of colon cancer.
| Cas No. | 71835-85-3 |
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| Purity | ≥97% |
| Formula | C18H18O4 |
| Formula Wt. | 298.33 |
| Chemical Name | 2-Phenylethyl3-(4-hydroxy-3-methoxyphenyl)-2- propenoate |
| IUPAC Name | 2-phenylethyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate |
| Synonym | CCRIS 7791 |
| Melting Point | 80-81°C |
| Solubility | Sol in ethanol, methanol, and most organic solvents. |
| Appearance | Off-white solid |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Samaha HS, Kelloff GJ, Steele V, et al. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 1997 Apr 1;57(7):1301-5. PMID: 9102217.
Rao CV, Desai D, Rivenson A, et al. Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Res. 1995 Jun 1;55(11):2310-5. PMID: 7757981.