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Phleomycin

Phleomycin

Product ID P2845
Cas No. 11006-33-0
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $126.00 In stock
25 mg $441.70 In stock
100 mg $1,325.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phleomycin is a glycopeptide antibiotic that binds DNA but does not intercalate. Phleomycin is mutagenic and requires metal ions to induce double-stranded DNA breaks. This compound displays some antibacterial and antifungal activities.

Product Info

Cas No.

11006-33-0

Purity

≥97%

Formula

C51H75N17O21S2

Formula Wt.

1326.38

IUPAC Name

2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-3-methyloxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-oxobutanoyl]amino]ethyl]-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazole-4-carboxamide

Synonym

NSC 61586, NSC 616586.

Solubility

Soluble in water (10 mg/mL); slightly soluble in methanol.

Appearance

Blue powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P2845 MSDS PDF

Info Sheet

P2845 Info Sheet PDF

References

van Peer AF, de Bekker C, Vinck A, et al. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75(5):1243-7. PMID: 19114524.

Povirk LF, Hogan M, Dattagupta N, et al. Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding. Biochemistry. 1981 Feb 3;20(3):665-71. PMID: 6163448.

Sleigh MJ. The mechanism of DNA breakage by phleomycin in vitro. Nucleic Acids Res. 1976 Apr;3(4):891-901. PMID: 818624.

Custom Order

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