• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Phomopsin A

Phomopsin A

Product ID P298576
Cas No. 64925-80-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $443.50 In stock
5 mg $1,788.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phomopsin A is a cyclic hexapeptide isolated from Phomopsis leptostromiformis. It is an antibiotic and a modifier of tubulin functions. It is a very potent inhibitor of microtubule assembly by binding to tubulin at a site different from the colchicine binding site. It has anti-proliferative activity against MCF-7 cells

Product Info

Cas No.

64925-80-0

Purity

≥98%

Formula

C36H45ClN6O12

Formula Wt.

789.24

Chemical Name

Phomopsin A

IUPAC Name

(E)-2-[[(E)-2-[[(2S)-1-[(2S,3S,6S,9S,10R)-14-chloro-10-ethyl-2,13-dihydroxy-10-methyl-3-(methylamino)-4,7-dioxo-6-prop-1-en-2-yl-11-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-9-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methylpent-2-enoyl]amino]but-2-enedioic acid

Synonym

Phomopsin; AC1O5PXJ; PHO-A; NSC 381839

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P298576 MSDS PDF

Info Sheet

P298576 Info Sheet PDF

References

Hamel E. Natural products which interact with tubulin in the vinca
domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and
15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51. PMID: 1287674

Li Y , Kobayashi H, Tokiwa Y, et al. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. Biochem Pharmacol. 1992, 43(2):219-24. PMID: 1739410

van Aswegen CH, Lewko WM, Wittliff JL. Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells. J Toxicol Environ Health. 1985;16(1):13-23. PMID: 4068051

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C000076

    C-176

    STING antagonist

    ≥99%
  • C4800

    CM346 Hydrochloride

    Potential anxiolytic.

    ≥99%
  • L3250

    D-Limonene

    Terpene found in the rind of various citrus fru...

    ≥97%
  • T6833

    Triacetyl Aloe-emodin (Impurity A)

    Derivative of aloe-emodin, anthraquinone found ...

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%
  • N5768

    Norfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • D0253

    Danazol

    Ethisterone derivative, synthetic steroid, used fo...
    ≥99%
  • T1652

    Teniposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥97%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • I7360

    Isosorbide Mononitrate

    NO donor.

    ≥98%
  • R183731

    Resiquimod

    Toll-like receptor 7/8 agonist

    ≥98%
  • G0145

    Gallic Acid

    Phenol found in various plant sources, used to ...

    ≥98%
  • D3430

    Dihydrosanguinarine

    Benzophenanthridine alkaloid, sanguinarine meta...

    ≥98%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • O4556

    Olomoucine

    Purine derivative; CDK inhibitor.

    ≥98%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only