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Phomopsin A

Phomopsin A

Product ID P298576
Cas No. 64925-80-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $443.50 In stock
5 mg $1,788.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phomopsin A is a cyclic hexapeptide isolated from Phomopsis leptostromiformis. It is an antibiotic and a modifier of tubulin functions. It is a very potent inhibitor of microtubule assembly by binding to tubulin at a site different from the colchicine binding site. It has anti-proliferative activity against MCF-7 cells

Product Info

Cas No.

64925-80-0

Purity

≥98%

Formula

C36H45ClN6O12

Formula Wt.

789.24

Chemical Name

Phomopsin A

IUPAC Name

(E)-2-[[(E)-2-[[(2S)-1-[(2S,3S,6S,9S,10R)-14-chloro-10-ethyl-2,13-dihydroxy-10-methyl-3-(methylamino)-4,7-dioxo-6-prop-1-en-2-yl-11-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-9-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methylpent-2-enoyl]amino]but-2-enedioic acid

Synonym

Phomopsin; AC1O5PXJ; PHO-A; NSC 381839

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P298576 MSDS PDF

Info Sheet

P298576 Info Sheet PDF

References

Hamel E. Natural products which interact with tubulin in the vinca
domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and
15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51. PMID: 1287674

Li Y , Kobayashi H, Tokiwa Y, et al. Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. Biochem Pharmacol. 1992, 43(2):219-24. PMID: 1739410

van Aswegen CH, Lewko WM, Wittliff JL. Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells. J Toxicol Environ Health. 1985;16(1):13-23. PMID: 4068051

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