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Pizotyline is a stimulant that acts as an antagonist at 5-HT2C receptors and as a partial agonist at 5-HT1A receptors. Pizotyline is clinically used to treat migraines, but also inhibits drug-induced lever press responding in drug discrimination models.
| Cas No. | 5189-11-7 |
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| Purity | ≥98% |
| Formula | C19H21NS • C4H6O5 |
| Formula Wt. | 429.54 |
| Chemical Name | 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4ylidene)-1-methylpiperidine |
| IUPAC Name | 4-(4,5-dihydrobenzo[1,2]cyclohepta[3, 4-b]thiophen-10-ylidene)-1-methylpiperidine;2-hydroxybutanedioic acid |
| Synonym | Pizotifen, Pizotifan, BC105 |
| Melting Point | 185-186°C (dec) |
| Solubility | Very slightly soluble in water. Slightly soluble in chloroform and ethanol. |
| Appearance | White or almost white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Young R, Khorana N, Bondareva T, et al. Pizotyline effectively attenuates the stimulus effects of N-methyl-3,4-methylenedioxyamphetamine (MDMA). Pharmacol Biochem Behav. 2005 Oct;82(2):404-10. PMID: 16253319.
Strachan AT, Leiper JB, Maughan RJ. Serotonin2C receptor blockade and thermoregulation during exercise in the heat. Med Sci Sports Exerc. 2005 Mar;37(3):389-94. PMID: 15741836.
Newman-Tancredi A, Conte C, Chaput C, et al. Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):682-8. PMID: 9205951.