• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Ponatinib

Ponatinib

Product ID P577520
Cas No. 943319-70-8
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $88.60 In stock
25 mg $170.40 In stock
100 mg $402.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ponatinib is a pan-Bcr-Abl tyrosine kinase inhibitor. It shows efficacy in the treatment of chronic myeloid leukemia (CML) as a second or third line treatment or against Bcr-Abl mutants. It is also an approved treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia, where it specifically targets the Bcr-Abl mutation T315I.

Product Info

Cas No.

943319-70-8

Purity

≥99%

Formula

C29H27F3N6O

Formula Wt.

532.57

Chemical Name

3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide

IUPAC Name

3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide

Synonym

AP-24534, AP 24534, AP24534, Iclusig

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P577520 MSDS PDF

Info Sheet

P577520 Info Sheet PDF

References

O’Hare T., SHakespeare W., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 16(5):401-12 (2009). PMID: 19878872.

Tan F., Putoczki T., et al. Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies. Onco Targets Ther. 12:1635-645 (2019). PMID: 30705592.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O1178

    n-Octyl-3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.

    ≥95%
  • A5202

    Anabasine Hydrochloride

    Alkaloid originally found in species of Nicotia...

    ≥98%
  • W9600

    WZ-4002

    EGFR (T790M) inhibitor.

    ≥98%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • F8272

    Fusarenon X

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%
  • P2400

    Phenethyl Caffeate

    Found in propolis; 5-lipoxygenase inhibitor.

    ≥98%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A985132

    AZD-8186

    Selective inhibitor of PI3Kβ and PI3Kδ.

    ≥99%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • D1720

    Deferiprone

    Iron chelator.

    ≥99%
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • M0275

    Mastoparan 17

    Peptide, inactive mastoparan analog used to mea...

    ≥95%
  • A5334

    Anisodamine

    Tropane alkaloid found in Solanaceae plants; α...

    ≥97%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • W7201

    WS6

    Islet α/β cell proliferation stimulator.

    ≥98%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • K0282

    Kavalactones Mixture

    Mixture of kavalactones found in Piper methysti...

    ≥98%
  • T5968

    Torsemide

    Loop diuretic; NKCC symporter and HSP90 inhibit...

    ≥99%
  • C2802

    CH5132799

    p110α PI3K inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only