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Ponatinib

Ponatinib

Product ID P577520
Cas No. 943319-70-8
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $88.60 In stock
25 mg $170.40 In stock
100 mg $402.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ponatinib is a pan-Bcr-Abl tyrosine kinase inhibitor. It shows efficacy in the treatment of chronic myeloid leukemia (CML) as a second or third line treatment or against Bcr-Abl mutants. It is also an approved treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia, where it specifically targets the Bcr-Abl mutation T315I.

Product Info

Cas No.

943319-70-8

Purity

≥99%

Formula

C29H27F3N6O

Formula Wt.

532.57

Chemical Name

3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide

IUPAC Name

3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide

Synonym

AP-24534, AP 24534, AP24534, Iclusig

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P577520 MSDS PDF

Info Sheet

P577520 Info Sheet PDF

References

O’Hare T., SHakespeare W., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 16(5):401-12 (2009). PMID: 19878872.

Tan F., Putoczki T., et al. Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies. Onco Targets Ther. 12:1635-645 (2019). PMID: 30705592.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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