LKT Labs

Biochemicals for Life Science Research

PP-242

PP-242

Product ID P6004
Cas No. 1092351-67-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $87.00 In stock
5 mg $144.00 In stock
10 mg $211.00 In stock
25 mg $481.00 In stock
Bulk Quote

Quicklinks

Description

PP-242 is an inhibitor of mTORC1/2 that displays anticancer chemotherapeutic and anti-metastatic activities. In various cellular models of acute leukemia, PP-242 inhibits cell proliferation. In animal models of pheochromocytoma, PP-242 induces apoptosis, upregulates expression of Bax, downregulates expression of Bcl-2, and decreases tumor volume. In gastric cancer cells, this compound also inhibits cell proliferation, migration, and invasion and suppresses tube formation and vascular invasion.

Product Info

Cas No.

1092351-67-1
Purity

≥98%
Formula

C16H16N6O
Formula Wt.

308.34
IUPAC Name

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
Synonym

Pp242, PP242, PP 242, Torkinib
Solubility

DMSO 61 mg/mL (197.83 mM) Ethanol 18 mg/mL (58.37 mM) Water Insoluble
Appearance

Tan to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P6004 MSDS PDF
Info Sheet

P6004 Info Sheet PDF

References

Shi F, Yang X, Gong Y, et al. The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. Anticancer Drugs. 2015 Apr;26(4):410-21. PMID: 25535978.

Zhang X, Wang X, Qin L, et al. The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. Urology. 2015 Jan;85(1):273.e1-7. PMID: 25440763.

Xing X, Zhang L, Wen X, et al. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anticancer Drugs. 2014 Nov;25(10):1129-40. PMID: 25035961.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A985132

    AZD-8186

    Selective inhibitor of PI3Kβ and PI3Kδ.

    ≥99%
  • A454470

    L-Allylglycine

    Inhibitor of glutamic acid decarboxylase (GAD)....

    ≥98%
  • K1676

    Ketoconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • P6802

    Pranoprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • Z2268

    Z-FR-AMC

    Protease substrate.

    ≥95%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • G8225

    Guggulsterone

    Steroid found in myrrh; FXR antagonist.

    ≥98%
  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • C9673

    Cysteamine Hydrochloride

    Aminothiol, CoA component; ulcer inducer.

    ≥99%
  • P9870

    Pyridostatin Hydrochloride

    G-quadruplex ligand; DNA breakage inducer.

    ≥97%
  • B022691

    Baricitinib

    Selective and reversible JAK inhibitor.

    ≥99%
  • P2303

    Phallacidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥98%
  • V1854

    Venlafaxine Hydrochloride

    SERT, NET, MAO inhibitor.

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • L186858

    Levomefolic acid

    Folic acid derivative

    ≥98%
  • V0147

    Valproic Acid Sodium

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%