LKT Labs

Biochemicals for Life Science Research

Prednisone

Product ID P7020
Cas No. 53-03-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $38.30 In stock
25 g $509.50 In stock
5 g $140.20 In stock
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Description

Prednisone is a synthetic corticosteroid/glucocorticoid that exhibits no biological activity until converted to its active metabolite, prednisolone. Once converted, this compound exhibits anti-inflammatory, immunosuppressive, anti-allergic, neuroprotective, and anticancer chemotherapeutic activities. Prednisone is one component of the CHOP chemotherapeutic cocktail that is clinically used to treat leukemias and lymphomas; in animal models of subarachnoid hemorrhage, CHOP inhibits neuronal apoptosis. Prednisone also inhibits expression of IL-6 and is clinically used to treat rheumatoid arthritis.

Product Info

Cas No.

53-03-2
Purity

≥98%
Formula

C21H26O5
Formula Wt.

358.43
Chemical Name

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
IUPAC Name

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10, 13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3, 11-dione
Synonym

Ancortone, Colisone, Decortin, Hostacortine, Orasone, Paracort, Sone, Ultracorten
Melting Point

233-235°C (dec)
Solubility

Slightly soluble in water and ethanol (6.5 mg/mL).

Appearance

White to practically white, odorless crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P7020 MSDS PDF
Info Sheet

P7020 Info Sheet PDF

References

Hoy SM. Bendamustine: a review of its use in the management of chronic lymphocytic leukaemia, rituximab-refractory indolent non-Hodgkin's lymphoma and multiple myeloma. Drugs. 2012 Oct 1;72(14):1929-50. PMID: 22950536.

Clarke L, Kirwan J. Efficacy, safety and mechanism of action of modified-release prednisone in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):159-66. PMID: 22850902.

He Z, Ostrowski RP, Sun X, et al. CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage. Stroke. 2012 Feb;43(2):484-90. PMID: 22180248.

Manns MP, Strassburg CP. Therapeutic strategies for autoimmune hepatitis. Dig Dis. 2011;29(4):411-5. PMID: 21894012.

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