LKT Labs

Biochemicals for Life Science Research

Pregnenolone

Product ID P7023
Cas No. 145-13-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $47.60 In stock
25 g $131.00 In stock
100 g $357.30 In stock
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Description

Pregnenolone is the endogenous precursor to all steroid hormones; it exhibits neuromodulatory, cognition enhancing, and antipsychotic activities. Pregnenolone decreases the negative symptoms of schizophrenia and increases attention and working memory performance in schizophrenic subjects. Pregnenolone sulfate acts as a positive allosteric NMDA receptor potentiator and a negative allosteric GABA-A receptor potentiator. Additionally, pregnenolone sulfate activates transient receptor potential melanostatin (TRPM3) channels, increasing Ca2+ influx and insulin secretion in islet cells.

Product Info

Cas No.

145-13-1
Purity

≥98%
Formula

C21H32O2
Formula Wt.

316.48
Chemical Name

(3β)-3-Hydroxypregn-5-en-20-one
IUPAC Name

1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Melting Point

193°C
Solubility

Sparingly soluble in water. Soluble in ethyl acetate (1:1), acetone (0.006g/mL) and ethanol (.010g/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P7023 MSDS PDF
Info Sheet

P7023 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Kostakis E, Smith C, Jang MK, et al. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug;84(2):261-74. PMID: 23716622.

Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. PMID: 21756978.

Wagner TF, Loch S, Lambert S, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30. PMID: 18978782.

Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett. 1988 Aug 1;90(3):279-84. PMID: 3138576.

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