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Proctolin is an endogenous excitatory neuromodulatory peptide found in crustaceans and insects. Proctolin exhibits vasoconstrictive activity, increasing vascular resistance and increasing antennae-heart beat rates in vivo. Additionally, in other in vivo models, proctolin modulates vitellogenin uptake. Release of proctolin can be induced by stretch-related stimulation.
| Cas No. | 57966-42-4 |
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| Purity | ≥95% |
| Formula | C30H48N8O8 |
| Formula Wt. | 648.77 |
| IUPAC Name | 2-[[1-[2-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid |
| Synonym | Gut factor. |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wilkens J. Possible mechanisms of control of vascular resistance in the lobster Homarus americanus J Exp Biol. 1997;200(Pt 3):487-93. PMID: 9318157.
Hertel W, Richter M, Rapus J, et al. The role of proctolin in the antenna-heart beat acceleration of Periplaneta americana (L.). Acta Biol Hung. 1995;46(2-4):491-506. PMID: 8853723.
Goudey-Perrière F, Perrière C, Brousse-Gaury P. Proctolin promotes vitellogenesis onset in the imaginal molt decapitated cockroach Blaberus craniifer. Comp Biochem Physiol Comp Physiol. 1994 Aug;108(4):533-42. PMID: 7915658.
Pasztor VM, Lange AB, Orchard I. Stretch-induced release of proctolin from the dendrites of a lobster sense organ. Brain Res. 1988 Aug 16;458(1):199-203. PMID: 2905194.