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Puromycin Aminonucleoside

Puromycin Aminonucleoside

Product ID P8167
Cas No. 58-60-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $112.60 In stock
25 mg $277.90 In stock
100 mg $818.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Puromycin is an aminonucleoside antibiotic compound originally produced by Streptomyces alboniger. Puromycin displays antibacterial activity through inhibition of ribosomal protein translation; it resembles the 3’ end of tRNA and is incorporated into growing protein chains through the ribosomal A site, inducing premature chain termination. Puromycin also induces DNA damage mediated by ROS and oxidative stress in animal models. In vitro, puromycin inhibits insulin-stimulated glycolysis by inhibiting insulin activation of phosphofructokinase 2. Puromycin also inhibits dipeptidyl peptidase II (DPP2; serine peptidase) and metallopeptidase. Additionally, this compound induces ERK activation-dependent apoptosis and mTOR-dependent autophagy in podocytes, leading to proteinuria and glomerular damage.

Product Info

Cas No.

58-60-6

Purity

≥98%

Formula

C12H18N6O3

Formula Wt.

294.31

IUPAC Name

(2R,3R,4S, 5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol

Synonym

Stylomycin aminonucleoside

Melting Point

215-216°C

Solubility

DMSO: 50mg/ml Water: 10mg/ml

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P8167 MSDS PDF

Info Sheet

P8167 Info Sheet PDF

References

Kang YL, Saleem MA, Chan KW, et al. The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes. Biochem Biophys Res Commun. 2014 Jan 10;443(2):628-34. PMID: 24333414.

Liu S, Ding J, Fan Q, et al. The activation of extracellular signal-regulated kinase is responsible for podocyte injury. Mol Biol Rep. 2010 Jun;37(5):2477-84. PMID: 19728154.

Marshall CB, Pippin JW, Krofft RD, et al. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int. 2006 Dec;70(11):1962-73. PMID: 17035936.

Probst I, Quentmeier A, Schweickhardt C, et al. Stimulation by insulin of glycolysis in cultured hepatocytes is attenuated by extracellular ATP and puromycin through purine-dependent inhibition of phosphofructokinase 2 activation. Eur J Biochem. 1989 Jun 15;182(2):387-93. PMID: 2525468.

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