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Pyridostatin Hydrochloride

Pyridostatin Hydrochloride

Product ID P9870
Cas No. 1085412-37-8
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $177.20 In stock
10 mg $278.60 In stock
25 mg $582.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pyridostatin is a G-quadruplex ligand that induces conformation changes in telomere-G-quadruplex complexes and stimulates double-stranded DNA breakage; it also alters telomere function. Pyridostatin displays antiviral and anticancer activities. In vitro, this compound decreases synthesis of Epstein-Barr virus-encoded nuclear antigen 1. In cancer cells, pyridostatin suppresses cellular viability and growth.

Product Info

Cas No.

1085412-37-8

Purity

≥97%

Formula

C31H32N8O5 • 3HCl

Formula Wt.

706.03

IUPAC Name

4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide;trihydrochloride

Synonym

Pyridostatin Trihydrochloride

Solubility

H2O: 15 mg/mL

Appearance

Pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P9870 MSDS PDF

Info Sheet

P9870 Info Sheet PDF

References

Marchand A, Granzhan A, Iida K, et al. Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes. J Am Chem Soc. 2015 Jan 21;137(2):750-6. PMID: 25525863.

Murat P, Zhong J, Lekieffre L, et al. G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation. Nat Chem Biol. 2014 May;10(5):358-64. PMID: 24633353.

McLuckie KI, Di Antonio M, Zecchini H, et al. G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc. 2013 Jul 3;135(26):9640-3. PMID: 23782415.

Müller S, Sanders DA, Di Antonio M, et al. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem. 2012 Aug 28;10(32):6537-46. PMID: 22790277.

Custom Order

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