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Pyridostatin trifluoroacetate is a G-quadruplex ligand that induces conformation changes in telomere-G-quadruplex complexes and stimulates double-stranded DNA breakage; it also alters telomere function. Pyridostatin displays antiviral and anticancer activities. In vitro, this compound decreases synthesis of Epstein-Barr virus-encoded nuclear antigen 1. In cancer cells, pyridostatin suppresses cellular viability and growth.
| Cas No. | 1472611-44-1 |
|---|---|
| Purity | ≥95% |
| Formula | C33H33F3N8O7 |
| Formula Wt. | 710.67 |
| Chemical Name | 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt |
| IUPAC Name | 4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide;2,2,2-trifluoroacetic acid |
| Synonym | Pyridostatin TFA salt, CCG-270392, Ethyl 4-(4-biphenylyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Marchand A, Granzhan A, Iida K, et al. Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes. J Am Chem Soc. 2015 Jan 21;137(2):750-6. PMID: 25525863.
Murat P, Zhong J, Lekieffre L, et al. G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation. Nat Chem Biol. 2014 May;10(5):358-64. PMID: 24633353.
McLuckie KI, Di Antonio M, Zecchini H, et al. G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc. 2013 Jul 3;135(26):9640-3. PMID: 23782415.
Müller S, Sanders DA, Di Antonio M, et al. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org Biomol Chem. 2012 Aug 28;10(32):6537-46. PMID: 22790277.