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Rocuronium is an aminosteroid that exhibits anesthetic activity, inducing relaxation of skeletal muscle. Rocuronium is a non-depolarizing neuromuscular junction (NMJ) blocker that inhibits post-synaptic nicotinic acetylcholine receptors (nAChRs); it also inhibits M2/3 muscarinic acetylcholine receptors (mAChRs). Rocuronium has a rapid onset and can be administered with a specific antagonist that terminates its action.
| Cas No. | 119302-91-9 |
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| Purity | ≥98% |
| Formula | C32H53BrN2O4 |
| Formula Wt. | 609.68 |
| IUPAC Name | [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10, 13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2, 3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;bromide |
| Melting Point | 162-164°C |
| Solubility | Soluble in water, ethanol, DMSO, chloroform, methanol. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pape A, Kertscho H, Stein P, et al. Neuromuscular blockade with rocuronium bromide increases the tolerance of acute normovolemic anemia in anesthetized pigs. Eur Surg Res. 2012;48(1):16-25. PMID: 22189343.
Bowman WC. Neuromuscular block. Br J Pharmacol. 2006 Jan;147 Suppl 1:S277-86. PMID: 16402115.
Hou VY, Hirshman CA, Emala CW. Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors. Anesthesiology. 1998 Mar;88(3):744-50. PMID: 9523819.