• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Roscovitine

Roscovitine

Product ID R5774
Cas No. 186692-46-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.30 In stock
5 mg $193.30 In stock
10 mg $286.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels; it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.

Product Info

Cas No.

186692-46-6

Purity

≥98%

Formula

C19H26N6O

Formula Wt.

354.45

Chemical Name

2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino- 9-isopropylpurine

IUPAC Name

(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol

Synonym

Seliciclib, CYC202

Melting Point

106-109°C

Solubility

Soluble in DMSO or chloroform.

Appearance

White crystalline solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R5774 MSDS PDF

Info Sheet

R5774 Info Sheet PDF

References

Leitch AE, Haslett C, Rossi AG. Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents. Br J Pharmacol. 2009 Oct;158(4):1004-16. PMID: 19775281.

Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels. Br J Pharmacol. 2007 Oct;152(3):386-95. PMID: 17700718.

Lacrima K, Rinaldi A, Vignati S, et al. Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas. Leuk Lymphoma. 2007 Jan;48(1):158-67. PMID: 17325859.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P5747

    Polymyxin B sulfate

    Cationic lipid polypeptide, mixture of polymyxi...

    ≥6500 iu/mg
  • D0244

    Dalcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • S3449

    Simvastatin

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%
  • D3200

    Diacetoxyscirpenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • F4556

    Florfenicol

    Synthetic fluorinated thiamphenicol analog; pro...

    ≥98%
  • E7857

    Etofenamate

    NSAID; COX-1/2 and lipoxygenase inhibitor.

    ≥98%
  • C0148

    Calcitonin, human

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • E5057

    Emodin

    Anthraquinone found in various plant sources; C...

    ≥95%
  • C0149

    Calcitonin, salmon

    Endogenous neuropeptide hormone, lowers extrace...

    ≥98%
  • R2513

    RGDS

    Tetrapeptide, binds cell surface integrins.

    ≥95%
  • G1308

    GDC-0032

    PI3K inhibitor.

    ≥98%
  • G3553

    Ginsenoside Rb2

    Triterpene saponin found in species of Panax.

    ≥98%
  • J0001

    J-147

    Phenyl hydrazide; neuronal oxidative stress inh...

    ≥98%
  • A0776

    ABT-199

    BH3 mimetic; Bcl-2 inhibitor.

    ≥99%
  • P200002

    PF-07321332

    Inhibitor of coronaviruses

    ≥99%
  • P6264

    PPQ-102

    Pyramido-pyrrolo-quinoxalinedione; CFTR blocker...

    ≥98%
  • T3040

    Thienylpentyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • C4510

    Climbazole

    14-α demethylase inhibitor.

    ≥99%
  • F8272

    Fusarenon X

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only