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R,S-Sulforaphane, Research Grade

R,S-Sulforaphane, Research Grade

Product ID S8047
Cas No. 4478-93-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $147.20 In stock
250 mg $447.60 In stock
1 g $939.10 Please Inquire
5 g $2,997.40 Please Inquire
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

R,S-Sulforaphane is a synthetic isothiocyanate. R-Sulforaphane is the naturally-occurring isomer, found in broccoli. This compound exhibits antioxidative, neuroprotective, anti-inflammatory, anti-atherosclerotic, neuromodulatory, cardioprotective, anticoagulant, antibiotic, anticancer chemotherapeutic, and chemopreventive activities; research suggests that the R-isomer may be more bioactive than the S-isomer. R,S-Sulforaphane induces activity and expression of phase II enzymes, inhibits the aryl hydrocarbon receptor, and downregulates expression of HDACs and STAT5. In cellular and animal models of melanoma, this compound inhibits tumor growth and cell proliferation. R,S-Sulforaphane also induces autophagy. In animal models of Alzheimer’s disease, R,S-sulforaphane lessens cognitive impairment. Additionally, this compound increases activity of Nrf2 and expression of catalase, protecting against UV-induced oxidative damage in ex vivo models. In other animal models, R,S-sulforaphane inhibits TNF-α-induced adhesion of monocytes to epithelial cells and decreases levels of VCAM-1. In myocytes, this compound prevents angiotensin II-induced hypertrophy. Additionally, R,S-sulforaphane inhibits platelet aggregation by suppressing PI3K/Akt signaling. R,S-Sulforaphane also displays antibacterial efficacy against Escherichia.

Please note: This compound is a neat liquid at room temperature, clear to slightly yellow in color. It is not dissolved in solvent. In small quantities the material will coat the sides of the ampule it is shipped in and may appear to be invisible, or it may be trapped in the tip of the ampule. Wash the upper and lower parts of the ampoule with solvent to ensure all of the material is obtained.

Product Info

Cas No.

4478-93-7

Purity

≥97%

Formula

C6H11NOS2

Formula Wt.

177.29

Chemical Name

1-Isothiocyanato-4-(methylsulfinyl)-butane

IUPAC Name

1-isothiocyanato-4-methylsulfinylbutane

Synonym

D,L-Sulforaphane, Sulforaphane

Solubility

Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO.

Appearance

Slight yellowish liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S8047 MSDS PDF

Info Sheet

S8047 Info Sheet PDF

References

Holcombe L, Holman J, Hurd M, et al. Early life exposure to brocoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease. mSystems. 2023 Dec 21;8(6):e0068823. PMID: 37942948.

Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556.

Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440.

Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493.

Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998.

Wu QQ, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363.

Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007.

Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129.

Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329.

Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.

Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243.

Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783.

Christine A. Houghton, Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 2716870, 27 pages https://doi.org/10.1155/2019/2716870

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