• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
R,S-Sulforaphane, Research Grade

R,S-Sulforaphane, Research Grade

Product ID S8047
Cas No. 4478-93-7
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $147.20 In stock
250 mg $447.60 In stock
1 g $939.10 In stock
5 g $2,997.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

R,S-Sulforaphane is a synthetic isothiocyanate. R-Sulforaphane is the naturally-occurring isomer, found in broccoli. This compound exhibits antioxidative, neuroprotective, anti-inflammatory, anti-atherosclerotic, neuromodulatory, cardioprotective, anticoagulant, antibiotic, anticancer chemotherapeutic, and chemopreventive activities; research suggests that the R-isomer may be more bioactive than the S-isomer. R,S-Sulforaphane induces activity and expression of phase II enzymes, inhibits the aryl hydrocarbon receptor, and downregulates expression of HDACs and STAT5. In cellular and animal models of melanoma, this compound inhibits tumor growth and cell proliferation. R,S-Sulforaphane also induces autophagy. In animal models of Alzheimer’s disease, R,S-sulforaphane lessens cognitive impairment. Additionally, this compound increases activity of Nrf2 and expression of catalase, protecting against UV-induced oxidative damage in ex vivo models. In other animal models, R,S-sulforaphane inhibits TNF-α-induced adhesion of monocytes to epithelial cells and decreases levels of VCAM-1. In myocytes, this compound prevents angiotensin II-induced hypertrophy. Additionally, R,S-sulforaphane inhibits platelet aggregation by suppressing PI3K/Akt signaling. R,S-Sulforaphane also displays antibacterial efficacy against Escherichia.

Please note: This compound is a neat liquid at room temperature, clear to slightly yellow in color. It is not dissolved in solvent. In small quantities the material will coat the sides of the ampule it is shipped in and may appear to be invisible, or it may be trapped in the tip of the ampule. Wash the upper and lower parts of the ampoule with solvent to ensure all of the material is obtained.

Product Info

Cas No.

4478-93-7

Purity

≥97%

Formula

C6H11NOS2

Formula Wt.

177.29

Chemical Name

1-Isothiocyanato-4-(methylsulfinyl)-butane

IUPAC Name

1-isothiocyanato-4-methylsulfinylbutane

Synonym

D,L-Sulforaphane, Sulforaphane

Solubility

Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO.

Appearance

Slight yellowish liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S8047 MSDS PDF

Info Sheet

S8047 Info Sheet PDF

References

Holcombe L, Holman J, Hurd M, et al. Early life exposure to brocoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease. mSystems. 2023 Dec 21;8(6):e0068823. PMID: 37942948.

Lee JH, Jeong JK, Park SY. Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway. Neuroscience. 2014 Oct 10;278:31-9. PMID: 25130556.

Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440.

Nallasamy P, Si H, Babu PV, et al. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. J Nutr Biochem. 2014 Aug;25(8):824-33. PMID: 24880493.

Pinz S, Unser S, Rascle A. The natural chemopreventive agent sulforaphane inhibits STAT5 activity. PLoS One. 2014 Jun 9;9(6):e99391. PMID: 24910998.

Wu QQ, Zong J, Gao L, et al. Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy. Herz. 2014 May;39(3):390-6. PMID: 23784363.

Kleszczyński K, Ernst IM, Wagner AE, et al. Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013 Dec;78:28-40. PMID: 24121007.

Chuang WY, Kung PH, Kuo CY, et al. Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway. Thromb Haemost. 2013 Jun;109(6):1120-30. PMID: 23426129.

Thakkar A, Sutaria D, Grandhi BK, et al. The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer. Oncol Rep. 2013 Apr;29(4):1671-7. PMID: 23404329.

Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.

Wu HZ, Fei HJ, Zhao YL, et al. Antibacterial mechanism of sulforaphane on Escherichia coli. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):386-90. PMID: 22812243.

Do DP, Pai SB, Rizvi SA, et al. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010 Feb 15;386(1-2):114-21. PMID: 19922783.

Christine A. Houghton, Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 2716870, 27 pages https://doi.org/10.1155/2019/2716870

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E5456

    Enocitabine

    Cytarabine derivative, nucleoside (cytosine) an...

    ≥95%
  • P7358

    Psoralen

    Furanocoumarin found in Psoralea coryfolia, DNA...

    ≥98%
  • S0344

    Salermide

    SIRT inhibitor.

    ≥98%
  • C0006

    Cabozantinib

    VEGFR2, c-Met, RET inhibitor.

    ≥98%
  • P3463

    Piperacillin Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • T1014

    7-TES-Paclitaxel

    Synthesis impurity

    ≥95%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • J023736

    (±)-Jasmonic Acid

    Phytohormone

    ≥98% (sum of isomers)
  • D1759

    Deoxynivalenol

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • M185770

    5-Methyltetrahydrofolic Acid

    Folic acid derivative

    ≥98%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • T1008

    10,13-Bissidechain Paclitaxel

    Synthesis impurity

    ≥90%
  • I5357

    Inositol

    Endogenous sugar produced from glucose, require...

    ≥98%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • G124088

    GDC-1971

    SHP2 inhibitor

    ≥99%
  • F4780

    Fluoxetine Hydrochloride

    FIASMA, SERT inhibitor, 5-HT and σ1 antagonist...

    ≥98%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only