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SFLLR

SFLLR

Product ID S2044
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $130.80 Please Inquire
2 mg $220.70 Please Inquire
5 mg $392.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SFLLR is a peptide agonist of protease-activated receptor type 1 (PAR1, also known as the thrombin receptor) that induces platelet adhesion and aggregation, mimicking the effects of thrombin. SFLLR exhibits pro-thrombotic, pro-angiogenic, and pro-inflammatory activities. In vagal motor neurons, SFLLR induces apoptosis. SFLLR increases release of pro-matrix metalloproteinase 9 (pro-MMP9) from fibroblasts in a JAK/STAT3-dependent manner; it also increases expression of matrix metalloproteinase 2 (MMP2) and induces angiogenesis in endothelial cells. SFLLR increases release of IL-6 from T cells as well. Additionally, this peptide can increase Na+ current in cardiomyocytes.

Product Info

Purity

≥95%

Formula

C30H50N8O7

Formula Wt.

634.78

Synonym

Thrombin Receptor Agonist (1-5)

Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S2044 MSDS PDF

Info Sheet

S2044 Info Sheet PDF

References

Wu X, Zhang W, Li JY, et al. Induction of apoptosis by thrombin in the cultured neurons of dorsal motor nucleus of the vagus. Neurogastroenterol Motil. 2011 Mar;23(3):279-85, e123-4. PMID: 21143557.

Pinet C, Algalarrondo V, Sablayrolles S, et al. Protease-activated receptor-1 mediates thrombin-induced persistent sodium current in human cardiomyocytes. Mol Pharmacol. 2008 Jun;73(6):1622-31. PMID: 18326052.

Wang L, Luo J, He S. Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release. BMC Cell Biol. 2007 May 7;8:14. PMID: 17480240.

Li T, He S. Induction of IL-6 release from human T cells by PAR-1 and PAR-2 agonists. Immunol Cell Biol. 2006 Oct;84(5):461-6. PMID: 16869943.

Maragoudakis ME, Kraniti N, Giannopoulou E, et al. Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists. Endothelium. 2001;8(3):195-205. PMID: 11824472.

Sabo T, Gurwitz D, Motola L, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10. PMID: 1332704.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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