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SGX-523

SGX-523

Product ID S2792
Cas No. 1022150-57-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $67.80 In stock
5 mg $210.40 In stock
25 mg $601.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SGX-523 is an inhibitor of MET that exhibits anticancer chemotherapeutic activity. SGX-523 inhibits growth of cells and tumors in models of non-small cell lung cancer (NSCLC). SGX-523 also improves the efficacy of co-administered treatments, further suppressing growth in animal models of lung cancer, breast cancer, and pancreatic cancer.

Product Info

Cas No.

1022150-57-7

Purity

≥98%

Formula

C18H13N7S

Formula Wt.

359.41

Chemical Name

6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline

IUPAC Name

6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline

Synonym

SGX523

Solubility

DMSO 3 mg/mL warmed (8.34 mM) Water Insoluble Ethanol Insoluble

Appearance

Brown solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S2792 MSDS PDF

Info Sheet

S2792 Info Sheet PDF

References

Zhang YW, Staal B, Essenburg C, et al. Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR. Mol Cancer Ther. 2013 Aug;12(8):1429-41. PMID: 23720767.

Zhang YW, Staal B, Essenburg C, et al. MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res. 2010 Sep 1;70(17):6880-90. Erratum in: Cancer Res. 2011 Apr 1;71(7):2804. PMID: 20643778.

Buchanan SG, Hendle J, Lee PS, et al. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther. 2009 Dec;8(12):3181-90. PMID: 19934279.

Custom Order

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