• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Simufilam

Simufilam

Product ID S336505
Cas No. 1224591-33-6
Purity
Product Unit SizeCostQuantityStock
1 mg $102.90 Please Inquire
5 mg $257.30 Please Inquire
25 mg $656.30 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Simufilam was first introduced as having the potential to reduce biomarkers of Alzheimer’s disease. The original data has since become suspect and could not be found. Fraud charges have been filed by the SEC. Simufilam may or may not have some useful bioactivities. The proper research, with proper data collection and analysis, is still to be done.

Product Info

Cas No.

1224591-33-6

Formula

C15H21N3O

Formula Wt.

259.35

Chemical Name

1-benzyl-8-methyl-1,4,8-triazaspiro(4.5)decan-2-one

IUPAC Name

4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one

Synonym

PTI-125; PTI-910; C0105; 1,4,8-Triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)-

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

S336505 Info Sheet PDF

References

Pillar C. Research backing experimental Alzheimer’s drug was first target of suspicion. Science. 2022 Jul 22;377(6604):363. PMID: 35862516

Pillar C. Probe of Alzheimer’s studies finds ‘egregious misconduct’. Science. 2023 Oct 20;382(6668):251-252. PMID: 37856608

Dyer O. Scientist who worked on Cassava’s Alzheimer drug simufilam charged with fraud. BMJ. 2024 Jul 15: 386:q1568. PMID: 39009358

Frontiers Editorial Office. Expression of concern: simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes. Front Aging. 2024 Aug 22:5:1483030. PMID: 39239266

Pillar C. Firm misled investors on Alzheimer’s drug, SEC charges. Science. 2024 Oct 4;386(6717):15. PMID: 39361735

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • S020665

    Saquinavir

    Protease inhibitor

    ≥99%
  • C8500

    CV-65

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • A5314

    Dehydroandrographolide

    Labdane diterpene found in Andrographis.

    ≥98%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • C2950

    Chloroquine Diphosphate

    Aminoquinoline, binds heme, causes cell lysis.<...

    ≥98%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • F1854

    Fenticonazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • N3476

    Nitisinone

    Nitrobenzene; HPPD inhibitor.

    ≥99%
  • A7604

    ATB 346

    NSAID; COX inhibitor and HS-releasing agent.

    ≥99%
  • T5611

    δ-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • F441026

    Flavopiridol Hydrochloride

    Semisynthetic flavone that acts as an inhibitor...

    ≥98%
  • E6134

    Epimedin C

    Flavonoid found in Epimedium sagittatum.

    ≥98%
  • B1874

    Bestatin Hydrochloride

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • A0401

    Abacavir

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%
  • I4962

    Isoimperatorin

    Furocoumarin; COX-2 inhibitor.

    ≥98%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only