Description
SMI-4a is a thiazolidine inhibitor of Pim kinase that displays anticancer chemotherapeutic activity. SMI-4a prevents phosphorylation of eIF4B and suppresses tumor growth in animal models of cancer. In myeloid and lymphoid cells, SMI-4a induces G1 phase cell cycle arrest, apoptosis, and cell death. Additionally, this compound delays tumor growth in animal models of precursor T-cell lymphoblastic leukemia/lymphoma.