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SMI-4a

SMI-4a

Product ID S4932
Cas No. 438190-29-5
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $84.40 In stock
10 mg $143.70 In stock
25 mg $295.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SMI-4a is a thiazolidine inhibitor of Pim kinase that displays anticancer chemotherapeutic activity. SMI-4a prevents phosphorylation of eIF4B and suppresses tumor growth in animal models of cancer. In myeloid and lymphoid cells, SMI-4a induces G1 phase cell cycle arrest, apoptosis, and cell death. Additionally, this compound delays tumor growth in animal models of precursor T-cell lymphoblastic leukemia/lymphoma.

Product Info

Cas No.

438190-29-5

Purity

≥99%

Formula

C11H6F3NO2S

Formula Wt.

273.23

IUPAC Name

(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione

Solubility

DMSO 55 mg/mL (201.29 mM) Ethanol 32 mg/mL (117.11 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S4932 MSDS PDF

Info Sheet

S4932 Info Sheet PDF

References

Yang J, Wang J, Chen K, et al. eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res. 2013 Aug 1;73(15):4898-908. PMID: 23749639.

Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28;115(4):824-33. PMID: 19965690.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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