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Somatostatin-28 (1-12)

Somatostatin-28 (1-12)

Product ID S5752
Cas No. 81286-16-0
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $131.30 Please Inquire
2 mg $207.90 Please Inquire
5 mg $399.00 Please Inquire
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities. In vivo, somatostatin improves performance in the light/dark avoidance test. Somatostatin also suppresses seizures and prevents the generation of seizures, potentially through modulation of GABA signaling. Somatostatin induces cell death under hypoxic/ischemic conditions. In tumor cells, somatostatin displays pro-apoptotic properties, potentially involving the inhibition of PI3K/Akt signaling. Somatostatin also limits food intake and inhibits secretion of insulin and glucagon through alteration of Gβγ signaling and P/Q-type N-type, and L-type voltage-gated Ca2+ channel signaling.

Product Info

Cas No.

81286-16-0

Purity

≥95%

Formula

C49H81N17O19S

Formula Wt.

1244.36

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]pentanedioic acid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S5752 MSDS PDF

Info Sheet

S5752 Info Sheet PDF

References

Stumm R. Somatostatin receptor sst2 reduces Akt activity and aggravates hypoxic/ischemic death in cerebral cortical neurons. Neuropharmacology. 2014 Feb;77:249-56. PMID: 24157493.

Takahashi M, Takeda M, Matsumoto S. Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons. Brain Res Bull. 2014 Jan;100:76-83. PMID: 24321530.

Albrecht A, Thiere M, Bergado-Acosta JR, et al. Circadian modulation of anxiety: a role for somatostatin in the amygdala. PLoS One. 2013 Dec 20;8(12):e84668. PMID: 24376834.

Kovac S, Walker MC. Neuropeptides in epilepsy. Neuropeptides. 2013 Dec;47(6):467-75. PMID: 24210141.

Begg DP, Woods SC. Interactions between the central nervous system and pancreatic islet secretions: a historical perspective. Adv Physiol Educ. 2013 Mar;37(1):53-60. PMID: 23471249.

Schwetz TA, Ustione A, Piston DW. Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E211-21. PMID: 23211512.

Kailey B, van de Bunt M, Cheley S, et al. SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1107-16. PMID: 22932785.

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