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SRT1720 Hydrochloride

SRT1720 Hydrochloride

Product ID S7868
Cas No. 1001645-58-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $78.80 In stock
5 mg $173.30 In stock
25 mg $446.30 In stock
100 mg $1,207.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SRT1720 is an inhibitor of sirtuin 3 (SIRT3) and activator of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). SRT1720 exhibits nephroprotective, anti-aging, anti-inflammatory, and pro-angiogenic activities. SRT1720 binds the acetyl-Lys site on sirtuins rather than the NAD+ site. In animal models of kidney ischemia/reperfusion injury, SRT1720 improves renal tubular pathology and overall renal function. In animal models fed high fat diets, SRT1720 delays the onset of metabolic diseases and decreases levels of pro-inflammatory cytokines, extending animal lifespan. In animal models of macular degeneration, this compound suppresses activation of NF-κB and release of IL-6, IL-8, and MMP-9, decreasing amyloid-β (Aβ)-induced retinal pigment epithelial barrier disruption. Additionally, SRT1720 increases VEGF secretion and promotes migration and metastasis of breast cancer cells in vitro and in vivo.

Product Info

Cas No.

1001645-58-4

Purity

≥98%

Formula

C25H23N7OS • HCl

Formula Wt.

506.02

IUPAC Name

N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride

Synonym

SRT-1720 HCl salt

Solubility

DMSO 38 mg/mL (75.09 mM) Water Insoluble Ethanol Insoluble

Appearance

Light tan to light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S7868 MSDS PDF

Info Sheet

S7868 Info Sheet PDF

References

Mitchell SJ, Martin-Montalvo A, Mercken EM, et al. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell Rep. 2014 Mar 13;6(5):836-43. PMID: 24582957.

Cao L, Liu C, Wang F, et al. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway. Braz J Med Biol Res. 2013 Aug;46(8):659-69. PMID: 24036938.

Nguyen GT, Schaefer S, Gertz M, et al. Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1423-32. PMID: 23897466.

Fan H, Yang HC, You L, et al. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. Kidney Int. 2013 Mar;83(3):404-13. PMID: 23302720.

Suzuki K, Hayashi R, Ichikawa T, et al. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol Rep. 2012 Jun;27(6):1726-32. PMID: 22470132.

Custom Order

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