• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Thapsigargin

Thapsigargin

Product ID T2801
Cas No. 67526-95-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $128.20 In stock
5 mg $537.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Thapsigargin is a sesquiterpene lactone found in Thapsia that is used in research models to induce endoplasmic reticulum (ER) stress. Thapsigargin inhibits SERCA Ca2+ pumps and may induce autophagy or apoptosis.

Product Info

Cas No.

67526-95-8

Purity

≥98%

Formula

C34H50O12

Formula Wt.

650.75

Chemical Name

Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2- methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)- azuleno(4,5-b)furan-7-yl ester, (3S-(3α,3aβ,4α,6β,- 6aβ,7β,8α(Z),9bα))-

IUPAC Name

[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3, 3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5, 6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

Synonym

Thapsigargine, Tg

Solubility

Soluble in DMSO, ethanol, or acetonitrile.

Appearance

Colorless film

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T2801 MSDS PDF

Info Sheet

T2801 Info Sheet PDF

References

Li Y, Liu Y, Zhang Y, et al. In vitro and in vivo evaluation of thapsigargin as an antiviral agent against transmissible gastroenteritis virus. Vet Res. 2024 Aug 2;55(1):97. PMID: 39095890.

Zhang X, Yuan Y, Jiang L, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. PMID: 25126734.

Wang H, Jia XZ, Sui CJ, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovial cells. ScientificWorldJournal. 2014 Feb 9;2014:605416. PMID: 24688409.

Rogers TB, Inesi G, Wade R, et al. Use of thapsigargin to study Ca2+ homeostasis in cardiac cells. Biosci Rep. 1995 Oct;15(5):341-9. PMID: 8825036.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M9645

    Myelin Oligodendrocyte Glycoprotein (35-55), rat

    Oligodendrocyte antigen used to induce EAE.

    ≥95%
  • Z1970

    Zerumbone

    Cyclic sesquiterpene found in ginger root; pote...

    ≥99%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • T5720

    Tofacitinib Citrate

    JAK1/2/3 inhibitor.

    ≥99%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%
  • A5035

    5-Aminosalicylic Acid

    Salicylic acid derivative; PPARγ agonist, pote...

    ≥98%
  • H0001

    H7

    PKC and PKG inhibitor.

    ≥98%
  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • C2847

    Chlormadinone Acetate

    Synthetic steroid hormone; AR and ER antagonist...

    ≥96%
  • B030960

    BAY-1082439

    PI3K inhibitor.

    ≥98%
  • M1575

    7-Methyl-6-mercaptopurine

    Thiopurine antimetabolite; PRPP amidotransferas...

    ≥87%
  • N0160

    NAP Peptide

    Octapeptide derived from activity-dependent neu...

    ≥95%
  • D8145

    Duloxetine Hydrochloride

    SERT and NET inhibitor, Nav1.7 Na+ channel bloc...

    ≥99%
  • E6231

    (−)-Epicatechin

    Flavanol originally found in Camilla (green tea...

    ≥93%
  • B1992

    Bexarotene

    RXR agonist.

    ≥98%
  • A745817

    Asunaprevir

    Antiviral againt SARS-CoV-2

    ≥98%
  • R2713

    Recombinant HCV-NS4 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • R3224

    Rigin

    Peptide, IgG derivative, tuftsin analog.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only